16856-18-1

Basic information

• Product Name: L-Arginine alpha-ketoglutarate
• Synonyms: L-ARGININE ALPHA-KETOGLUTARATE;L-ARGININE ALPHA-KETOGLUTARATE(1:1);l-arginine 2-oxoglutarate;L-ARGININE A-KETOGLUTARATE;L-ARGININE A-KETOGLUTARATE (1:1);L-Arginine-α-ketoglutarate;L-Arginine-Ketoglutarate Dihydrate;L-Arginine α-ketoglutarate(1:1)
• CAS NO: 16856-18-1
• Molecular Formula: C11H20N4O7
• Molecular Weight: 320.3
• EINECS: 240-882-6
• Product Categories: Nutritional Supplements;Food Additives;amino acid
• Mol File: 16856-18-1.mol

Chemical Properties

• Boiling Point: 646 °C at 760 mmHg
• Flash Point: 344.5 °C
• Appearance: /
• Vapor Pressure: 7.7E-08mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: L-Arginine alpha-ketoglutarate(CAS DataBase Reference)
• NIST Chemistry Reference: L-Arginine alpha-ketoglutarate(16856-18-1)
• EPA Substance Registry System: L-Arginine alpha-ketoglutarate(16856-18-1)

Safety Data

• Hazardous Substances Data: 16856-18-1(Hazardous Substances Data)

Usage

Uses

Used in Athletic Performance Enhancement:
L-Arginine alpha-ketoglutarate is used as a dietary supplement for enhancing athletic performance. It is believed to increase the production of nitric oxide in the body, which may improve blood flow and oxygen delivery to muscles during exercise, thereby promoting better physical performance.
Used in Muscle Growth Promotion:
In the fitness industry, L-Arginine alpha-ketoglutarate is used as a supplement to promote muscle growth. Some research suggests that AAKG may support the body's natural production of growth hormone, which aids in muscle development and recovery after intense physical activity.
Used in Cardiovascular Health Support:
L-Arginine alpha-ketoglutarate is used as a supplement in the health and wellness industry to support cardiovascular health. It has been studied for its potential to improve cardiovascular health and maintain healthy blood pressure levels, making it a beneficial addition to the diet of individuals seeking to maintain a healthy heart.
Overall, L-Arginine alpha-ketoglutarate is a versatile supplement with applications in athletic performance enhancement, muscle growth promotion, and cardiovascular health support, making it a popular choice among athletes, bodybuilders, and health-conscious individuals.

InChI:InChI=1/C6H14N4O2.C5H6O5/c7-4(5(11)12)2-1-3-10-6(8)9;6-3(5(9)10)1-2-4(7)8/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1-2H2,(H,7,8)(H,9,10)

Upstream product

• 74-79-3 L-arginine 
• 42964-50-1 dimethyl 2,2-dichloro-1,5-pentanedioate 

Relevant articles and documents

Process for preparation of alpha-ketoglutaric acid

A process for preparation of α-ketoglutaric acid, which is adapted for preparing L-arginine α-ketoglutarate 1:1 and 2:1, comprising the steps of: (a) reacting methyl dichloroacetate and acrylic acid methyl ester with sodium methoxide to obtain dimethyl 2,2-dichloroglutarate; (b) reacting the dimethyl 2,2-dichloroglutarate from step (a) with hydroxide solution to obtain crude α-ketoglutaratic acid aqueous solution; (c) purifying the crude α-ketoglutaratic acid aqueous solution to obtain purified α-ketoglutaratic acid aqueous solution; and (d) adjusting a concentration of the purified α-ketoglutaratic acid aqueous solution by adding water, thereby a yield of the purified α-ketoglutaratic acid aqueous solution is approximately 75%. While avoiding the use of massive organic solvents, the process of the present invention has a remarkable high yield to realize mass production with low manufacturing cost and shortened production time.

Process for preparation of L-Arginine alpha-ketoglutarate 1:1 and 2:1

A process for preparation of α-ketoglutaric acid, L-arginine α-ketoglutarate 1:1 and 2:1, comprising the steps of: providing a α-ketoglutaratic acid aqueous solution at an adjusted concentration; adding one equivalent mole of solid L-arginine to the α-ketoglutaratic acid aqueous solution; stirring and allowing reaction under a controlled temperature; (e) obtaining a resulting L-arginine α-ketoglutarate 1:1 solution with a pH of approximately 3?4 or L-arginine α-ketoglutarate 2:1 solution with a pH of approximately 6.5?7; and obtaining a final product of L-arginine α-ketoglutarate 1:1 or 2:1 through spay drying. The yield of the final product is approximately 94% for L-arginine α-ketoglutarate 1:1 and 97% for L-arginine α-ketoglutarate 2:1 through the process. Large amount of solvents is eliminated and reaction time is shortened but the yield is increased, hence realizing mass production through reactor in a cost and time effective manner.