16947-82-3

Basic information

• Product Name: BOC-CYS(ET)-OH
• Synonyms: N-ALPHA-T-BUTOXYCARBONYL-S-ETHYL-L-CYSTEINE;N-BOC-S-ETHYL-L-CYSTEINE;BOC-CYSTEINE(ET)-OH;BOC-CYS(SC2H5)-OH;BOC-CYS(ET)-OH;BOC-S-ETHYL-L-CYSTEINE;N-(tert-butoxycarbonyl)-S-ethyl-L-cysteine;Boc-Cys[S-Et]Oh
• CAS NO: 16947-82-3
• Molecular Formula: C₁₀H₁₉NO₄S
• Molecular Weight: 249.33
• Mol File: 16947-82-3.mol

Chemical Properties

• Boiling Point: 400.3 °C at 760 mmHg
• Flash Point: 195.9 °C
• Appearance: /
• Density: 1.16 g/cm³
• Vapor Pressure: 1.58E-07mmHg at 25°C
• Refractive Index: 1.5
• Storage Temp.: -15°C
• PKA: 3.58±0.10(Predicted)
• CAS DataBase Reference: BOC-CYS(ET)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-CYS(ET)-OH(16947-82-3)
• EPA Substance Registry System: BOC-CYS(ET)-OH(16947-82-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 16947-82-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
BOC-CYS(ET)-OH is used as a synthetic building block for the creation of peptides with specific sequences tailored for various therapeutic applications. Its role in peptide synthesis is crucial for developing new drugs with targeted functionalities.
Used in Biochemistry:
In the field of biochemistry, BOC-CYS(ET)-OH is utilized as a component in the assembly of peptides that can be used to study protein-protein interactions, enzyme mechanisms, and other biological processes. BOC-CYS(ET)-OH's structural elements allow for the exploration of peptide conformation and function.
Used in Peptide Drug Development:
BOC-CYS(ET)-OH is employed as a key intermediate in the development of peptide-based drugs, where its protected cysteine and ethyl linker contribute to the stability and bioavailability of the final therapeutic peptide.
Used in Chemical Synthesis:
In chemical synthesis, BOC-CYS(ET)-OH serves as a reagent for the preparation of complex organic molecules, including those with potential applications in materials science and other specialized fields.
Used in Academic Research:
BOC-CYS(ET)-OH is used as a research tool in academic settings to explore the fundamental aspects of peptide chemistry, including synthesis methods, protecting group strategies, and the study of peptide folding and stability.

InChI:InChI=1/C10H19NO4S/c1-5-16-6-7(8(12)13)11-9(14)15-10(2,3)4/h7H,5-6H2,1-4H3,(H,11,14)(H,12,13)/t7-/m0/s1

Upstream product

• 2629-59-6 S-ethyl-L-cysteine 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

Derivative of Kutkin dimer analog JJA-D0 or its pharmaceutically acceptable salt, preparation method and use thereof

The invention relates to a derivative of Kutkin dimer analog JJA-D0 or its pharmaceutically acceptable salt, a preparation method and use thereof. The compound has a structure shown as a general formula (I). According to the invention, an alkyl group, an aryl group, a heteroaryl group, an alkoxycarbonylalkyl group, an acyl group, a sulfonate group, an antioxidant group such as a lipoic acid group,a H2S donor group such as a cysteine group, and a NO donor group such as a nitrate group are introduced to JJA-D0, and a series of structurally novel compounds can be synthesized and disclosed. The compounds inhibit NADPH oxidase and have superior anti-oxidation and anti-inflammatory pharmacological mechanisms by comparing with Kutkin, the compounds also have donor groups that provide NO and H2S,can further enhance pharmacological activity, and can be a new class of multifunctional compounds. The disclosed JJA-D0 derivative can be used for preparing health products or drugs for prevention ortreatment of diseases associated with NADPH oxidase, diseases associated with free radicals, diseases associated with inflammation, diseases associated with NO, and diseases associated with H2S.

Exploration of the P1 SAR of aldehyde cathepsin K inhibitors.

The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S(1) subsite with a series of alpha-amino aldehyde derivatives substituted at the P(1) position afforded compounds with cathepsin K IC(50)s between 52 microM and 15 nM.