cas 169545-27-1, IRL-2500 | Articles data ｜lookchem

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169545-27-1

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BISAMIDE COMPOUNDS AS ALLOSTERIC EFFECTORS FOR REDUCING THE OXYGEN-BINDING AFFINITY OF HEMOGLOBIN
This invention relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, which are allosteric effectors that reduce the oxygen-binding affinity of hemoglobin, which can enhance the efficacy of radiation therapy for cancer and which are useful for the treatment of ischemia and other conditions.
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(2015/07/23)

Antagonists of endothelin receptors
The present invention provides novel compounds having pharmacological properties represented by the general formula I STR1 processes for the manufacture, pharmaceutical compositions and the use of the compounds of formula I and salts thereof.
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(2008/06/13)

IRL 2500: A potent ET(B) selective endothelin antagonist
Combination of a glycine substitution scan on the C-terminal dodecapeptide analog of ET-1 and a substance P antagonist screen on the basis of a homology study of the rhodopsin superfamily of seven-transmembrane receptors yielded in the development of IRL 2500, a potent ET(B) selective endothelin antagonist.
Frueh,Saika,Svensson,Pitterna,Sakaki,Okada,Urade,Oda,Fujitani,Takimoto,Yamamura,Inui,Makatani,Takai,Umemura,Teno,Toh,Hayakawa,Murata
p. 2323 - 2328
(2007/10/03)

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Chemical Properties

Appearance/Colour :White crystalline solid
Melting Point: 83-88oC
Boiling Point: 893.7 °C at 760 mmHg
Flash Point:494.3 °C
Density: 1.246g/cm³
Storage Temp.:Desiccate at RT
Vapor Pressure: 2.56E-34mmHg at 25°C
Refractive Index: 1.652
PSA: 102.50000
LogP: 6.33800

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