Peptidyl compounds and their therapeutic use as inhibitors of metalloproteinases
The present invention concerns novel mercaptoalkylpeptidyl compounds of formula (I) which are useful inhibitors of matrix metalloproteinase and/or TNF-mediated diseases including degenerative diseases and certain cancers. The invention also concerns methods of treating patients suffering from disorders or diseases which can be attributed to or are associated with matrix metalloproteinase or TNF activity.
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(2008/06/13)
Mercaptoacyl matrix metalloproteinase inhibitors: The effect of substitution at the mercaptoacyl moiety
The in vitro potency of orally-active mercaptoacyl matrix metalloproteinase inhibitors is increased by the introduction of appropriate substitutents on the mercaptoacyl moiety.
Baxter, Andrew D.,Bhogal, Ranjev,Bird, John B.,Buckley, George M.,Gregory, David S.,Hedger, Paul C.,Manallack, David T.,Massil, Tracy,Minton, Kevin J.,Montana, John G.,Neidle, Stephen,Owen, David A.,Watson, Robert J.
p. 2765 - 2770
(2007/10/03)
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