- Process for producing cycloalkyl [b]benzofurans
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The present invention provides a process for producing an optically active compound of cycloalkyl[b]benzofuran using a readily available optically active compound as a starting material by a reaction using a transition metal or the Mitsunobu reaction, or
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- Synthesis of optically active cyclopenta[b]benzofuran as a precursor of m-phenyleneprostacyclin
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The optically pure cyclopenta[b]benzofuran derivatives (-)-1 and (-)-2 were synthesized from (+)-(1S,4R)-cis-4-acetoxy-2-cyclopenten-1-ol [(+)-3] via sequential Mitsunobu reaction and palladium-catalyzed allylic substitution with phenol derivatives followed by SN2′ intramolecular cyclization.
- Nishiyama, Hisao,Sakata, Naoya,Sugimoto, Hayato,Motoyama, Yukihiro,Wakita, Hisanori,Nagase, Hiroshi
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p. 930 - 932
(2007/10/03)
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- Chemoenzymatic synthesis of trans-4,5-dihydroxycyclopent-2-enones: Conversion to D-1-deoxynojirimycin
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(4R,5S)-trans-4,5-Bis(tert-butyldimethylsilyloxy)cyclopent-2-enone 8 and (4R,5S)-trans-4,5-di(benzyloxy)cyclopent-2-enone 20 are prepared by equilibration of the corresponding cis derivatives; enone 8 is transformed into the glucosidase inhibitor, D-1-deoxynojirimycin 14.
- Johnson,Nerurkar,Golebiowski,Sundram,Esker
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p. 1139 - 1140
(2007/10/02)
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