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(4-Phenoxyphenyl)methylamine Hydrochloride is a chemical compound that is commonly utilized in research and development settings. It is an amine derivative, characterized by the presence of a basic nitrogenous group, with one of its aromatic rings substituted by a phenoxy group. The hydrochloride form of this compound is a salt variant, which significantly improves its solubility in water. As with many chemical compounds, it is essential to follow proper safety protocols to mitigate potential health hazards such as skin or eye irritation, respiratory irritation, and other risks. Comprehensive handling procedures and potential hazards should be outlined in the compound's Safety Data Sheet (SDS).

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  • 169944-04-1 Structure
  • Basic information

    1. Product Name: (4-PHENOXYPHENYL)METHYLAMINE HYDROCHLORIDE
    2. Synonyms: (4-PHENOXYPHENYL)METHYLAMINE HYDROCHLORIDE;4-PHENOXYBENZYLAMINE HCL;(4-Phenoxyphenyl)MethanaMine hydrochloride;(4-Phenoxyphenyl)
    3. CAS NO:169944-04-1
    4. Molecular Formula: C13H14ClNO
    5. Molecular Weight: 235.70936
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 169944-04-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 351.7°C at 760 mmHg
    3. Flash Point: 166.5°C
    4. Appearance: /
    5. Density: N/A
    6. Vapor Pressure: 2.84E-05mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. CAS DataBase Reference: (4-PHENOXYPHENYL)METHYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
    11. NIST Chemistry Reference: (4-PHENOXYPHENYL)METHYLAMINE HYDROCHLORIDE(169944-04-1)
    12. EPA Substance Registry System: (4-PHENOXYPHENYL)METHYLAMINE HYDROCHLORIDE(169944-04-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 169944-04-1(Hazardous Substances Data)

169944-04-1 Usage

Uses

Used in Organic Synthesis:
(4-Phenoxyphenyl)methylamine Hydrochloride is employed as an intermediate in organic synthesis processes. Its unique structure and reactivity make it a valuable component in the preparation of various complex organic molecules.
Used in Research and Development:
In the field of research and development, (4-Phenoxyphenyl)methylamine Hydrochloride is used as a key compound for exploring new chemical reactions and pathways. Its properties and behavior under different conditions can provide insights into the development of new synthetic methods and applications in chemistry.
Used in Pharmaceutical Industry:
(4-Phenoxyphenyl)methylamine Hydrochloride is used as a building block in the synthesis of pharmaceutical compounds. Its versatility in forming different types of chemical bonds and its potential to interact with biological targets make it a promising candidate for the development of new drugs.
Used in Chemical Research:
In the realm of chemical research, (4-Phenoxyphenyl)methylamine Hydrochloride is used to study the properties of amines and their derivatives. Its reactivity, stability, and interaction with other compounds can contribute to a deeper understanding of chemical principles and the design of new chemical entities.

Check Digit Verification of cas no

The CAS Registry Mumber 169944-04-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,9,9,4 and 4 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 169944-04:
(8*1)+(7*6)+(6*9)+(5*9)+(4*4)+(3*4)+(2*0)+(1*4)=181
181 % 10 = 1
So 169944-04-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H13NO.ClH/c14-10-11-6-8-13(9-7-11)15-12-4-2-1-3-5-12;/h1-9H,10,14H2;1H

169944-04-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (4-phenoxyphenyl)methanamine,hydrochloride

1.2 Other means of identification

Product number -
Other names (4-Phenoxyphenyl)methylamine hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:169944-04-1 SDS

169944-04-1Downstream Products

169944-04-1Relevant articles and documents

Bicyclic (alkyl)(amino)carbene (BICAAC) as a metal-free catalyst for reduction of nitriles to amines

Gautam, Nimisha,Logdi, Ratan,Mandal, Swadhin K.,Rajendran, N. M.,Sreejyothi, P.,Tiwari, Ashwani K.

supporting information, p. 3047 - 3050 (2022/03/14)

Bicyclic (alkyl)(amino)carbene (BICAAC) is introduced as a metal-free catalyst for the reduction of various nitriles to the corresponding amine hydrochloride salts in the presence of pinacolborane. Mechanistic investigations combining experiments and DFT calculations suggest a B-H addition to the carbene center, which acts as a carrier of the hydride source. This journal is

HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS

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Paragraph 0313-0314, (2020/07/16)

The present disclosure relates generally to compounds useful in treatment of conditions associated with mutant isocitrate dehydrogenase (mt-IDH), particularly mutant IDH1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against mutant IDH1 enzymes. Method of treating conditions associated with excessive activity of mutant IDH1 enzymes with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.

Synthesis of Molybdenum Pincer Complexes and Their Application in the Catalytic Hydrogenation of Nitriles

Leischner, Thomas,Spannenberg, Anke,Junge, Kathrin,Beller, Matthias

, p. 4543 - 4549 (2020/07/13)

A series of molybdenum(0), (I) and (II) complexes ligated by different PNP and NNN pincer ligands were synthesized and structurally characterized. Along with previously described Mo?PNP complexes Mo-1 and Mo-2, all prepared compounds were tested in the catalytic hydrogenation of aromatic nitriles to primary amines. Among the applied catalysts, Mo-1 is particularly well suited for the hydrogenation of electron-rich benzonitriles. Additionally, two aliphatic nitriles were transformed into the desired products in 80 and 86 percent, respectively. Moreover, catalytic intermediate Mo-1a was isolated and its role in the catalytic cycle was subsequently demonstrated.

Rapid Continuous Ruthenium-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines

Labes, Ricardo,González-Calderón, Davir,Battilocchio, Claudio,Mateos, Carlos,Cumming, Graham R.,De Frutos, Oscar,Rincón, Juan A.,Ley, Steven V.

supporting information, p. 2855 - 2858 (2017/10/06)

A continuous flow method for the selective reduction of aromatic nitriles to the corresponding amine is reported. The method is based on a ruthenium-catalysed transfer-hydrogenation process, requires no additives, and uses isopropanol as both solvent and reducing agent. The process utilizes 1 mol% of the commercially available [Ru(p -cymene)Cl 2 ] 2, with a residence time of ca. 9 min, and a throughput of 50 mmol/h. The method was successfully applied to a range of aromatic nitriles providing the corresponding primary amines in good yields.

Boron-Catalyzed Silylative Reduction of Nitriles in Accessing Primary Amines and Imines

Gandhamsetty, Narasimhulu,Jeong, Jinseong,Park, Juhyeon,Park, Sehoon,Chang, Sukbok

, p. 7281 - 7287 (2015/07/28)

Silylative reduction of nitriles was studied under transition metal-free conditions by using B(C6F5)3 as a catalyst with hydrosilanes as a reductant. Alkyl and (hetero)aryl nitriles were efficiently converted to primary amines or imines under mild conditions. The choice of silanes was found to determine the selectivity: while a full reduction of nitriles was highly facile, the use of sterically bulky silanes allowed for the partial reduction leading to N-silylimines.

COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS

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Page/Page column 261, (2010/11/19)

Disclosed is a composition for agricultural use, which is used for controlling or preventing plant diseases caused by plant pathogens. The composition for agricultural use contains a compound represented by formula (1), a salt thereof or a hydrate of the compound or the salt. (1) [In the formula, Z represents an oxygen atom, a sulfur atom or NRz; and E represents a furyl group, a thienyl group, a pyrrolyl group, a tetrazolyl group, a thiazolyl group, a pyrazolyl group, a phenyl group or the like.]

AMIDE COMPOUND AND METHOD OF CONTROLLING PLANT DISEASE WITH THE SAME

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Page/Page column 104, (2010/02/14)

A amid compound of the formula (1): wherein, in the formula, R51 represents a halogen atom, a C1-C6 alkyl group and the like; R52 represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group and the like; R53 represents a halogen atom and the like; R56 represents a halogen atom and the like; R57 represents a hydrogen atom and the like; R58 and R59 independently represent a hydrogen atom, a C1-C3 alkyl group and the like; R60 represents a C1-C4 alkyl group, a C1-C4 haloalkyl group, a C3-C4 alkenyl group, or a C3-C6 alkynyl group; R61 represents a C1-C4 alkyl group, a C1-C4 haloalkyl group, a C3-C4 alkenyl group or a C3-C6 alkynyl group or a C2-C4 cyanoalkyl group; R62, R63 and R64 represent a hydrogen atom, a halogen atom and the like; X represents a oxygen atom or a sulfur atom; has an excellent activity against plant diseases.

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