170098-88-1

Basic information

• Product Name: 1-Chloro-4-fluoro-2-Methyl-5-nitrobenzene
• Synonyms: 1-Chloro-4-fluoro-2-Methyl-5-nitrobenzene
• CAS NO: 170098-88-1
• Molecular Formula: C₇H₅ClFNO₂
• Molecular Weight: 189.5715032
• Mol File: 170098-88-1.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Chloro-4-fluoro-2-Methyl-5-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-4-fluoro-2-Methyl-5-nitrobenzene(170098-88-1)
• EPA Substance Registry System: 1-Chloro-4-fluoro-2-Methyl-5-nitrobenzene(170098-88-1)

Safety Data

• Hazardous Substances Data: 170098-88-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Chloro-4-fluoro-2-Methyl-5-nitrobenzene is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 1-Chloro-4-fluoro-2-Methyl-5-nitrobenzene serves as an intermediate in the production of agrochemicals. Its properties make it suitable for the creation of compounds that can be used in agriculture to protect crops and enhance yields.
Used in Dye Manufacturing:
1-Chloro-4-fluoro-2-Methyl-5-nitrobenzene is utilized as a starting material in the manufacturing of dyes. Its aromatic structure and functional groups enable the production of a range of dyes with specific color properties for various applications.
Used in Polymer Production:
1-Chloro-4-fluoro-2-Methyl-5-nitrobenzene is also used in the synthesis of polymers, where its chemical structure contributes to the development of polymers with特定的 properties for use in different industries, such as plastics, coatings, and adhesives.
Used in Organic Compounds Synthesis:
1-Chloro-4-fluoro-2-Methyl-5-nitrobenzene has potential applications in the synthesis of other organic compounds, where its unique combination of atoms and functional groups can be leveraged to create new molecules with specific characteristics for various uses in the chemical industry.

Upstream product

• 33406-96-1 2-chloro-5-fluorotoluene 

Downstream Products

• 932374-54-4 1,1-dimethylethyl 4-[(4-chloro-5-methyl-2-nitrophenyl)amino]-1-piperidinecarboxylate 

Relevant articles and documents

(1,1, 1,3, 3, 3-HEXAFLUORO-2-HYDROXYPROPAN-2-YL) PHENYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR USE FOR THE TREATMENT OF ATHEROSCLEROSIS

The present invention relates to (1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl derivatives having the general formula (I) to pharmaceutical compositions comprising the same and to the use of these (1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl

COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE

Compounds of formula (I) or a salt thereof are provided: (I) wherein R4, R5, R6, Q, n and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders and cognitive impairments are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.

BENZIMIDAZOLES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE

Compounds of Formula (I) and salts and solvates are provided; wherein R, R5, R6 and Q are defined as in the claims. Uses of the compounds for therapy, for example in the treatment of psychotic disorders and cognitive impairment, are also disclosed.

COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE

Compounds of formula (I) and salts and solvates are provided: In a first aspect therefore, the invention provides a compound of formula (I) or a salt or solvate thereof: wherein R5 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; R6 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; and Q is hydrogen or C 1-6 alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones

Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia, and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, and Down's syndrome, treating or preventing the adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions, and inducing anesthesia are disclosed by administering to an animal in need of such treatment an alkyl or azido-substituted 1,4-dihydroquinoxaline-2,3-dione or pharmaceutically acceptable salts thereof, which have high binding to the glycine receptor.

Regiospecific Oxidative Nitration of 3,4-Dihydro-6,7-disubstituted Quinoxalin-2(1H)-ones Gives 1,4-Dihydro-5-nitro-6,7-disubstituted Quinoxaline-2,3-diones, Potent Antagonists at the NMDA/Glycine Site

The regiospecific oxidative nitration of 3,4-dihydro-6,7-disubstituted quinoxalin-2(1H)-ones (15a-h, 20) utilizing fuming nitric acid in TFA gave 1,4-dihydro-5-nitro-6,7-disubstituted quinoxaline-2,3-diones (6a-i), respectively, in good yields.Compounds 15a-h were prepared from commercially available 1-halo-3,4-disubstituted benzenes 12a-h in three steps.These were nitration, nucleophilic substitution of the halogen ortho to the nitro group with sodium glycinate, and finally, reduction of the nitro group and concomitant cyclization.Compound 20 was prepared from 16 by a different route involving alkylation of substituted o-nitroaniline 18.The final oxidative nitration yields a single, predictable nitro isomer and is a significant improvement over the direct nitration of 6,7-disubstituted quinoxaline-2,3-diones.