Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino- 5-ethylpyrrolo[2,3-d]pyrimidines as antifolates
The classical antifolate N-{4-[(2,4-diamino-5-ethyl-7H-pyrrolo[2,3-d] pyrimidin-6-yl)sulfanyl]benzoyl}-L-glutamic acid (2) and 15 nonclassical analogues (3-17) were synthesized as potential dihydrofolate reductase (DHFR) inhibitors and as antitumor agents
Gangjee, Aleem,Zeng, Yibin,Talreja, Tina,McGuire, John J.,Kisliuk, Roy L.,Queener, Sherry F.
p. 3046 - 3053
(2008/02/09)
First Synthesis of 4H-Furo[3,2-f]pyrrolo[1,2-a][1,4]diazepines
The synthetic pathway leading to 4-H-furo[3,2-f]pyrrolo[1,2-a][1,4]diazepines is described in five steps starting from 2-hydroxyketones via 2-amino-3-furonitriles.