170230-39-4Relevant articles and documents
Substituted benzanilides as CCR5 receptors ligands, antiinflammatory agents and antiviral agents
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, (2008/06/13)
This invention relates to substituted benzanilides which are ligands, agonists or antagonists, of the CCR5 receptor. In addition, this invention relates to the treatment and prevention of disease states mediated by CCR5, including, but not limited to, ast
The selective 5-HT(1B) receptor inverse agonist 1-methyl-5-[[2'-methyl- 4'(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7- tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function bo
Gaster, Laramie M.,Blaney, Frank E.,Davies, Susannah,Duckworth, D. Malcolm,Ham, Peter,Jenkins, Sarah,Jennings, Andrew J.,Joiner, Graham F.,King, Frank D.,Mulholland, Keith R.,Wyman, Paul A.,Hagan, Jim J.,Hatcher, Jon,Jones, Brian J.,Middlemiss, Derek N.,Price, Gary W.,Riley, Graham,Roberts, Claire,Routledge, Carol,Selkirk, Julie,Slade, Paula D.
, p. 1218 - 1235 (2007/10/03)
5-HT1 receptors are members of the G-protein-coupled receptor superfamily and are negatively linked to adenylyl cyclase activity. The human 5-HT(1B) and 5-HT(1D) receptors (previously known as 5-HT(1Dβ) and 5- HT(1Dα), respectively), although e