Direct conversion of sulfinamides to thiosulfonates without the use of additional redox agents under metal-free conditions
Direct conversion of sulfinamides to thiosulfonates is described. Without the use of additional redox agents, the reaction proceeds smoothly in the presence of TFA under metal-free conditions. This protocol possesses many advantages such as odourless and stable starting materials, broad substrate scope, selective synthesis, and mild reaction conditions. This journal is
Ji, Yuan-Zhao,Li, Hui-Jing,Wang, Jun-Hu,Wu, Yan-Chao,Zhang, Chi
p. 9291 - 9298
(2021/11/13)
A new synthesis of cytotoxic thiosulfonates and the first synthesis of deuterated thiosulfonates
A new synthesis of thiosulfonates starting from thiophenols and cyanuric chloride activated dimethyl sulfoxide is reported herein. Although the yields of the reactions are moderate, this method enables the incorporation of the SCD3 group of dimethyl sulfoxide-d6 into thiosulfonates. This is the first synthesis of deuterated thiosulfonates with a labeling purity above 99%. In addition, the cytotoxicity of the thiosulfonates is reported for the first time. Georg Thieme Verlag Stuttgart. New York.