170493-66-0

Basic information

• Product Name: (2S)-1-(7-methoxyindeno[1,2-b]pyrrol-1(4H)-yl)propan-2-amine
• Synonyms: (2S)-1-(7-Methoxyindeno[1,2-b]pyrrol-1(4H)-yl)-2-propanamine; Indeno(1,2-b)pyrrole-1(4H)-ethanamine, 7-methoxy-alpha-methyl-, (alphaS)-; Indeno(1,2-b)pyrrole-1(4H)-ethanamine, 7-methoxy-alpha-methyl-, (S)-; indeno[1,2-b]pyrrole-1(4H)-ethanamine, 7-methoxy-alpha-methyl-, (alphaS)-
• CAS NO: 170493-66-0
• Molecular Formula: C₁₅H₁₈N₂O
• Molecular Weight: 242.3162
• Mol File: 170493-66-0.mol

Chemical Properties

• Boiling Point: 408.3°C at 760 mmHg
• Flash Point: 200.7°C
• Density: 1.2g/cm³
• Vapor Pressure: 7.08E-07mmHg at 25°C
• Refractive Index: 1.623
• CAS DataBase Reference: (2S)-1-(7-methoxyindeno[1,2-b]pyrrol-1(4H)-yl)propan-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-1-(7-methoxyindeno[1,2-b]pyrrol-1(4H)-yl)propan-2-amine(170493-66-0)
• EPA Substance Registry System: (2S)-1-(7-methoxyindeno[1,2-b]pyrrol-1(4H)-yl)propan-2-amine(170493-66-0)

Safety Data

• Hazardous Substances Data: 170493-66-0(Hazardous Substances Data)

Upstream product

• 170496-00-1 (RS)-1-(2-azido-propyl)-7-methoxy-1,4-dihydro-indeno[1,2-b]pyrrole 
• 13623-25-1 6-methoxy-2,3-dihydro-1H-inden-1-one 
• 170495-16-6 (RS)-2-(2-oxoethyl)-6-methoxy-1-indanone 
• 170495-98-4 (RS)-1-(7-methoxy-1,4-dihydro-indeno[1,2-b]pyrrol-1-yl)-propan-2-ol 
• 170495-99-5 Methanesulfonic acid 2-(7-methoxy-4H-indeno[1,2-b]pyrrol-1-yl)-1-methyl-ethyl ester 
• 170495-19-9 (S)-1-(2-azido-propyl)-7-methoxy-1,4-dihydro-indeno[1,2-b]pyrrole 
• 170495-17-7 (R)-1-(7-methoxy-1,4-dihydro-indeno[1,2-b]pyrrol-1-yl)-propan-2-ol 
• 170495-18-8 Methanesulfonic acid (R)-2-(7-methoxy-4H-indeno[1,2-b]pyrrol-1-yl)-1-methyl-ethyl ester 
• 170496-19-2 (R)-1-(2-azido-propyl)-7-methoxy-1,4-dihydro-indeno[1,2-b]pyrrole 
• 170496-17-0 (S)-1-(7-methoxy-1,4-dihydro-indeno[1,2-b]pyrrol-1-yl)-propan-2-ol 
• 170496-18-1 Methanesulfonic acid (S)-2-(7-methoxy-4H-indeno[1,2-b]pyrrol-1-yl)-1-methyl-ethyl ester 

Relevant articles and documents

Novel agonists of 5HT2C receptors. Synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2-b]pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder.

The syntheses of a series of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2- b]pyrrol-1-yl)-1-methylethylamines are reported. The binding affinities of the compounds at 5HT2C and 5HT2A receptors (79% homology in the transmembrane domain)

TRICYCLIC PYRROLE DERIVATIVES USEFUL AS 5-HT SELECTIVE AGENTS

The invention relates to tricyclic pyrrole derivatives useful as 5-HT selective agents of the formula STR1 wherein R 1 to R 4 are, independently, hydrogen, halogen, lower alkyl, phenyl, cycloalkyl or lower alkoxy and R 2 additionally is lower alkoxycarbonyl, acyloxy or mesyloxy;R 5 to R 7 are, independently, hydrogen or lower alkyl;X is--CH 2 CH(C 6 H. sub.5)--,--CH=C(C 6 H 5)--,--YCH 2--,--CH=CH--or--(CR 11 R 12) n ;R 11 and R 12 are, independently, hydrogen, phenyl, lower alkyl or halogen;n is 1 to 3 andy is O or S,as well as pharmaceutically acceptable salts of basic compounds of formula I with pharmaceutically acceptable acids.