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170570-76-0

1-(4-CHLORO-PHENYL)-4,4-DIFLUORO-BUTANE-1,3-DIONE is a chemical compound characterized by its molecular formula C10H9ClF2O2. It is a yellow crystalline solid that serves as a crucial building block in the realm of organic synthesis. This versatile compound is known for its applications in the production of pharmaceuticals, agrochemicals, and other fine chemicals, as well as its utility as a reagent in chemical reactions, particularly in the synthesis of heterocyclic compounds. Furthermore, it has garnered interest for its potential biological activities, such as anti-inflammatory and antioxidant properties.

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  • 170570-76-0 Structure

  • Basic information

    1. Product Name: 1-(4-CHLORO-PHENYL)-4,4-DIFLUORO-BUTANE-1,3-DIONE
    2. Synonyms: ART-CHEM-BB B007362;1-(4-CHLORO-PHENYL)-4,4-DIFLUORO-BUTANE-1,3-DIONE;AKOS B007362;AKOS MSC-0352
    3. CAS NO:170570-76-0
    4. Molecular Formula: C10H7ClF2O2
    5. Molecular Weight: 232.61
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 170570-76-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-(4-CHLORO-PHENYL)-4,4-DIFLUORO-BUTANE-1,3-DIONE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-(4-CHLORO-PHENYL)-4,4-DIFLUORO-BUTANE-1,3-DIONE(170570-76-0)
    11. EPA Substance Registry System: 1-(4-CHLORO-PHENYL)-4,4-DIFLUORO-BUTANE-1,3-DIONE(170570-76-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 170570-76-0(Hazardous Substances Data)

170570-76-0 Usage

Uses

Used in Pharmaceutical Industry:
1-(4-CHLORO-PHENYL)-4,4-DIFLUORO-BUTANE-1,3-DIONE is used as a building block for the production of various pharmaceuticals. Its unique structure and properties make it a valuable component in the development of new drugs and medications.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(4-CHLORO-PHENYL)-4,4-DIFLUORO-BUTANE-1,3-DIONE is utilized as a key component in the synthesis of agrochemicals. Its incorporation contributes to the effectiveness of these chemicals in agricultural applications.
Used in Fine Chemicals Production:
1-(4-CHLORO-PHENYL)-4,4-DIFLUORO-BUTANE-1,3-DIONE is also used as a building block in the production of fine chemicals, which are high-purity chemicals used in various industries, including pharmaceuticals, fragrances, and flavors.
Used as a Reagent in Chemical Reactions:
1-(4-CHLORO-PHENYL)-4,4-DIFLUORO-BUTANE-1,3-DIONE is employed as a reagent in various chemical reactions, particularly in the synthesis of heterocyclic compounds. Its reactivity and structural features make it a useful tool for chemists in creating complex molecular structures.
Used in Research and Development:
Due to its potential biological activities, such as anti-inflammatory and antioxidant properties, 1-(4-CHLORO-PHENYL)-4,4-DIFLUORO-BUTANE-1,3-DIONE is also used in research and development for exploring its possible applications in the medical and pharmaceutical fields.

Check Digit Verification of cas no

The CAS Registry Mumber 170570-76-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,0,5,7 and 0 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 170570-76:
(8*1)+(7*7)+(6*0)+(5*5)+(4*7)+(3*0)+(2*7)+(1*6)=130
130 % 10 = 0
So 170570-76-0 is a valid CAS Registry Number.

170570-76-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4,4-difluoro-1-[4-(chloro)phenyl]-butane-1,3-dione

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:170570-76-0 SDS

170570-76-0Downstream Products

170570-76-0Relevant articles and documents

Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine

Li, Jin,Lundy DeMello, Kristin M.,Cheng, Henry,Sakya, Subas M.,Bronk, Brian S.,Rafka, Robert J.,Jaynes, Burton H.,Ziegler, Carl B.,Kilroy, Carolyn,Mann, Donald W.,Nimz, Eric L.,Lynch, Michael P.,Haven, Michelle L.,Kolosko, Nicole L.,Minich, Martha L.,Li, Chao,Dutra, Jason K.,Rast, Bryson,Crosson, Rhonda M.,Morton, Barry J.,Kirk, Glen W.,Callaghan, Kathleen M.,Koss, David A.,Shavnya, Andrei,Lund, Lisa A.,Seibel, Scott B.,Petras, Carol F.,Silvia, Annette

, p. 95 - 98 (2007/10/03)

Structure-activity relationship (SAR) studies of 2-[3-di(and tri)fluoromethyl-5-arylpyrazol-1-yl]-5-methanesulfonylpyridine derivatives for canine COX enzymes are described. This led to the identification of 12a as a lead candidate for further progression. The in vitro and in vivo activity of 12a for the canine COX-2 enzyme as well as its in vivo efficacy and pharmacokinetic properties in dog are highlighted.

Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies

-

, (2008/06/13)

A method of using pyrazolyl benzenesulfonamide compounds in treating inflammation and inflammation-related disorders in companion animals is disclosed.

Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation

-

, (2008/06/13)

A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: STR1 or a pharmaceutically-acceptable salt thereof.

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: Identification of 4-[5-(4-methylphenyl)- 3(trifluoromethyl)-1h-pyrazol-1-yl]benzenesulfonamide (sc-58635, celecoxib)

Penning, Thomas D.,Talley, John J.,Bertenshaw, Stephen R.,Carter, Jeffery S.,Collins, Paul W.,Docter, Stephen,Graneto, Matthew J.,Lee, Len F.,Malecha, James W.,Miyashiro, Julie M.,Rogers, Roland S.,Rogier,Yu, Stella S.,Anderson, Gary D.,Burton, Earl G.,Cogburn, J. Nita,Gregory, Susan A.,Koboldt, Carol M.,Perkins, William E.,Seibert, Karen,Veenhuizen, Amy W.,Zhang, Yan Y.,Isakson, Peter C.

, p. 1347 - 1365 (2007/10/03)

A series of sulfonamide-containing 1,5-diarylpyrazole derivatives were prepared and evaluated for their ability to block cyclooxygenase-2 (COX-2) in vitro and in vivo. Extensive structure-activity relationship (SAR) work was carried out within this series, and a number of potent and selective inhibitors of COX-2 were identified. Since an early structural lead (1f, SC- 236) exhibited an unacceptably long plasma half-life, a number of pyrazole analogs containing potential metabolic sites were evaluated further in vivo in an effort to identify compounds with acceptable pharmacokinetic profiles. This work led to the identification of 1i (4-[5-(4-methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-y1]benzenesulfonamide, SC-58635, celecoxib), which is currently in phase III clinical trials for the treatment of rheumatoid arthritis and osteoarthritis.

Substituted pyrazolyl benzenesulfonamide for the treatment of inflammation

-

, (2008/06/13)

A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: STR1

SUBSTITUTED PYRAZOLYL BENZENESULFONAMIDES

-

, (2008/06/13)

A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: or a pharmaceutically-acceptable salt thereof

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