170728-95-7Relevant articles and documents
Condensed indoline derivatives and their use as 5HT, in particular 5HT2c, receptor ligands
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Page/Page column 9, (2010/02/13)
A chemical compound of formula (I) wherein R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 and R5 are selected from hydrogen and alkyl; R6 and R7 are independently selected from hydrogen, halogen, hydroxyl, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, alkylsulfoxyl, nitro, carbonitrile, carbo-alkoxy, carbo-aryloxy and carboxyl; and A is a 5- or 6-membered ring optionally containing one or more heteroatoms wherein the atoms of the ring A, other than the unsaturated carbon atoms of the phenyl ring to which the ring A is fused, are saturated or unsaturated, and pharmaceutically acceptable salts, addition compounds and prodrugs thereof; and the use thereof in therapy, particularly as an agonist or antagonist of a 5HT receptor, particularly a 5HT2C receptor, for instance in the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus, and sleep apnea, and particularly for the treatment of obesity.
Indoline derivatives as 5-HT2C receptor agonists
Bentley,Adams,Bebbington,Benwell,Bickerdike,Davidson,Dawson,Dourish,Duncton,Gaur,George,Giles,Hamlyn,Kennett,Knight,Malcolm,Mansell,Misra,Monck,Pratt,Quirk,Roffey,Vickers,Cliffe
, p. 2367 - 2370 (2007/10/03)
A series of 1-(1-indolinyl)-2-propylamines was synthesised and evaluated as 5-HT2C receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles are described. The functional efficacy and radioligand
