17075-15-9

Basic information

• Product Name: 4-(Methylsulfonyl)pyridine
• Synonyms: 4-(Methylsulfonyl)pyridine
• CAS NO: 17075-15-9
• Molecular Formula: C₆H₇NO₂S
• Molecular Weight: 157.19028
• Mol File: 17075-15-9.mol

Chemical Properties

• Melting Point: 81 °C
• Boiling Point: 340.9°C at 760 mmHg
• Flash Point: 160°C
• Appearance: /
• Density: 1.263g/cm³
• Vapor Pressure: 0.000165mmHg at 25°C
• Refractive Index: 1.522
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 1.85±0.10(Predicted)
• CAS DataBase Reference: 4-(Methylsulfonyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Methylsulfonyl)pyridine(17075-15-9)
• EPA Substance Registry System: 4-(Methylsulfonyl)pyridine(17075-15-9)

Safety Data

• Hazardous Substances Data: 17075-15-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-(Methylsulfonyl)pyridine is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(Methylsulfonyl)pyridine is employed as a precursor in the production of agrochemicals, aiding in the creation of compounds that can enhance crop protection and management.
Used in Organic Synthesis:
4-(Methylsulfonyl)pyridine is utilized as an intermediate in organic synthesis for the preparation of other organic compounds, showcasing its versatility in chemical reactions and its potential to contribute to the development of novel chemical entities.

InChI:InChI=1/C6H7NO2S/c1-10(8,9)6-2-4-7-5-3-6/h2-5H,1H3

Upstream product

• 22581-72-2 4-methylthiopyridine 
• 20277-69-4 sodium methansulfinate 
• 1692-15-5 4-pyridylboronic acid 
• 19829-29-9 4-pyridinethione 
• 21948-76-5 (+/-)-4-(methylsulfinyl)pyridine 
• 504-24-5 4-aminopyridine 

Relevant articles and documents

Selective Functionalization of Aminoheterocycles by a Pyrylium Salt

The functionalization of aminoheterocycles by using a pyrylium tetrafluoroborate reagent (Pyry-BF4) is presented. This reagent efficiently condenses with a great variety of heterocyclic amines and primes the C?N bond for nucleophilic aromatic substitution. More than 60 examples for the formation of C?O, C?N, C?S, or C?SO2R bonds are disclosed herein. In contrast to C?N activation through diazotization and polyalkylation, this method is characterized by its mild conditions and impressive functional-group tolerance. In addition to small-molecule derivatization, Pyry-BF4 allows the introduction of functional groups in a late-stage fashion to furnish highly functionalized structures.

Enzymatic synthesis of novel chiral sulfoxides employing Baeyer-villiger monooxygenases

Optically active sulfoxides are compounds of high interest in organic chemistry. Herein, we report the preparation of a set of chiral heteroaryl alkyl, cyclohexyl alkyl, and alkyl alkyl sulfoxides by using enantioselective sulfoxidation reactions employing three Baeyer-Villiger monooxygenases (BVMOs). Careful selection of the reaction conditions, starting sulfide, and biocatalyst can be used to achieve good to excellent enantiomeric excess values. Thus, valuable chiral synthons can be obtained by performing the reactions under mild and environmentally friendly conditions. The most promising biotransformations that employ a BVMO cell-free extract preparation have been developed on a 250-mg scale to give the chiral sulfoxides in high yields in most of the reactions. Copyright

A general copper-catalyzed sulfonylation of arylboronic acids

A general copper-catalyzed method for the sulfonylation of arylboronic acids with sulfinate salts is described. A variety of alkyl-aryl, diaryl, and alkyl-heteroaryl sulfones were synthesized in good yield.

Azetidine derivatives, their preparation and pharmaceutical compositions containing them

Compounds of formula: in which R represents a CR1R2, C═C(R5)SO2R6 or C═C(R7)SO2alk radical, their preparation and the pharmaceutical compositions containing them.