New enantioselective approach to α-allokainoids by Michael addition to chiral 4-substituted 2,3-didehydroprolinate
(-) and (+) α-Allokainoids hydrochlorides 3 and 4 were obtained by hydrolysis of the corresponding Michael adducts resulting from the addition of diethyl malonate to chiral N-urethane protected ethyl 4-benzyl-2,3-didehydroprolinates 9 and 13 respectively.
Ezquerra,Ezquerra, Jesus,Escribano,Escribano, Ana,Rubio,Rubio, Almudena,Remuinan,Remuinan, Modesto Jesus,Vaquero,Josevaquero, Juan
p. 6149 - 6152
(2007/10/02)
Highly Chemoselective Reduction of N-Boc Protected Lactams
N-Boc protected lactams can be reduced chemoselectively in the presence of other groups such as esters, nitriles carbamates or double bonds by first reducing the amide carbonyl group into the corresponding hemiaminal using lithium triethylborohydride foll
Pedregal, Concepcion,Ezquerra, Jesus,Escribano, Ana,Carreno, M. Carmen,Ruano, Jose L. Garcia
p. 2053 - 2056
(2007/10/02)
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