170981-26-7

Basic information

• Product Name: 2-Fluoro-4-methylphenylboronic acid
• Synonyms: 2-FLUORO-4-METHYLBENZENEBORONIC ACID;2-FLUORO-4-METHYLPHENYLBORONIC ACID;Boronic acid, (2-fluoro-4-methylphenyl)- (9CI);2-Fluoro-4-Methylphenylboronic;2-Fluoro-4-methylphenylboronic acid ,97%;2-Fluoro-4-methylphenylboronic Acid (contains varying amounts of Anhydride);2-Fluoro-4-methylphenylbo...;2-Fluoro-p-tolylboronic acid
• CAS NO: 170981-26-7
• Molecular Formula: C₇H₈BFO₂
• Molecular Weight: 153.95
• Product Categories: HALIDE;blocks;BoronicAcids;FluoroCompounds;Aryl;Halogenated;Organoborons;Aromatics Compounds;Boronic acid;Aromatics;Boron Derivatives;Boronic Acids;Boronic Acids and Derivatives;Boronic Acids;Aryl Boronic Acids;Boronic Acids and Derivatives;Chemical Synthesis;Disubstituted Aryl Boronic Acids;Organometallic Reagents
• Mol File: 170981-26-7.mol

Chemical Properties

• Melting Point: 228-233 °C(lit.)
• Boiling Point: 277.8 °C at 760 mmHg
• Flash Point: 121.8 °C
• Appearance: Off-white crystalline powder
• Density: 1.2 g/cm³
• Vapor Pressure: 0.00213mmHg at 25°C
• Refractive Index: 1.505
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 8?+-.0.58(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: 2-Fluoro-4-methylphenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-4-methylphenylboronic acid(170981-26-7)
• EPA Substance Registry System: 2-Fluoro-4-methylphenylboronic acid(170981-26-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-27-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 170981-26-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-4-methylphenylboronic acid is used as a reactant for the water-accelerated Pd-catalyzed Suzuki-Miyaura coupling, a widely employed method in the synthesis of pharmaceutical compounds. This reaction allows for the formation of carbon-carbon bonds, which are crucial for constructing complex organic molecules, including those with potential therapeutic properties.
Used in Organic Synthesis:
In the field of organic synthesis, 2-Fluoro-4-methylphenylboronic acid is used as a building block for the creation of various organic compounds. Its unique structure allows it to participate in a range of reactions, such as the Suzuki reaction, which is a type of cross-coupling reaction that forms carbon-carbon bonds. This makes it a versatile component in the synthesis of a wide array of organic molecules, including those with potential applications in materials science, agrochemicals, and other industries.
Used in Research and Development:
2-Fluoro-4-methylphenylboronic acid is also utilized in research and development settings, where it can be employed to study the effects of fluorination and methylation on the reactivity and properties of organic compounds. This can lead to the discovery of new synthetic routes, novel compounds, and a deeper understanding of the underlying chemical principles.

InChI:InChI=1/C7H8BFO2/c1-5-2-3-6(8(10)11)7(9)4-5/h2-4,10-11H,1H3

Upstream product

• 150-46-9 triethyl borate 
• 452-74-4 4-bromo-3-fluorotoluene 

Downstream Products

• 1613718-78-7 (R)-6-((3R,4R)-1,3-dimethylpiperidin-4-yl)-7-(2-fluoro-4-methylphenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one 
• 1445595-73-2 (S)-(3-(2-fluoro-4-methylphenyl)-6-methylpyridin-2-yl)(6-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)methanone 
• 1165936-03-7 2-(2-fluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1158982-10-5 4-(5-amino-3-trifluoromethyl-1H-1,2,4-triazol-1-yl)-3-fluorotoluene 
• 1231309-26-4 tert-butyl 2-(((1s,4s)-4-((5-ethyl-3-(2-fluoro-4-methoxyphenyl)-4-phenyl-1H-pyrazol-1-yl)methyl)cyclohexyl)methoxy)acetate 
• 1231307-48-4 2-(((1s,4s)-4-((5-(2-fluoro-4-methylphenyl)-3-methyl-4-phenyl-1H-pyrazol-1-yl)methyl)cyclohexyl)methoxy)acetic acid 
• 1231304-73-6 2-(((1s,4s)-4-((3-(2-fluoro-4-methylphenyl)-5-methyl-4-phenyl-1H-pyrazol-1-yl)methyl)cyclohexyl)methoxy)acetic acid 
• 1146543-16-9 4-(2-fluoro-4-methyl-phenyl)-pyrrolo[1,2-a]quinoline 
• 1029439-48-2 C₂₁H₁₅B₃Br₃F₃O₃ 
• 927436-01-9 5-(2-fluoro-4-methyl-phenyl)-pyridine-2-carboxylic acid methyl ester 
• 905281-16-5 tert-butyl (1S)-1-(1H-benzimidazol-2-yl)-2-{4-[(5S)-1,1-dioxido-3-oxoisothiazolidin-5-yl]-3-fluorophenyl}ethylcarbamate 
• 850321-79-8 methyl (2Z)-2-[(tert-butoxycarbonyl)amino]-3-[4-(2-tert-butyl-1,1-dioxido-3-oxoisothiazolidin-5-yl)-3-fluorophenyl]acrylate 

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