1710-66-3 Usage
Uses
Used in Pharmaceutical Industry:
Isothiazole-5-methanol is used as a key intermediate in the synthesis of 1β-methylcarbapenems, a class of antibiotics with isothiazoloethenyl side chains. These antibiotics exhibit potent antibacterial activities, making them effective against a wide range of bacterial infections. The incorporation of Isothiazole-5-methanol into the structure of these antibiotics enhances their efficacy and broadens their spectrum of activity, providing a valuable tool in the fight against antibiotic-resistant bacteria.
Check Digit Verification of cas no
The CAS Registry Mumber 1710-66-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,1 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1710-66:
(6*1)+(5*7)+(4*1)+(3*0)+(2*6)+(1*6)=63
63 % 10 = 3
So 1710-66-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H5NOS/c6-3-4-1-2-5-7-4/h1-2,6H,3H2
1710-66-3Relevant articles and documents
Synthesis and biological evaluation of novel 1β-methylcarbapenems with isothiazoloethenyl side chains
Kang, Yong Koo,Lee, Kyung Seok,Yoo, Kyung Ho,Shin, Kye Jung,Kim, Dong Chan,Lee, Chang-Seok,Kong, Jae Yang,Kim, Dong Jin
, p. 463 - 466 (2007/10/03)
The synthesis of novel 1β-methylcarbapenems 1a,b bearing isothiazoloethenyl moieties at C-5 position of pyrrolidine ring and their biological evaluation are described. Both compounds showed potent and well-balanced antibacterial activity as well as high stability to DHP-I. Especially, 5-isothiazole derivative 1a exhibited excellent DHP-I stability and advanced pharmacokinetics profiles, compared to 5-isoxazole derivative 2, imipenem, and meropenem.
