171011-37-3

Basic information

• Product Name: (4-bromo-1,2-phenylene)dimethanol
• Synonyms: (4-bromo-1,2-phenylene)dimethanol;[4-bromo-2-(hydroxymethyl)phenyl]methanol;1,2-Benzenedimethanol, 4-bromo-;(4-Bromo-1,2-phenylene)
• CAS NO: 171011-37-3
• Molecular Formula: C₈H₉BrO₂
• Molecular Weight: 217.05986
• Mol File: 171011-37-3.mol

Chemical Properties

• Melting Point: 84 °C
• Boiling Point: 361.8±32.0 °C(Predicted)
• Appearance: /
• Density: 1.628±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.06±0.10(Predicted)
• CAS DataBase Reference: (4-bromo-1,2-phenylene)dimethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (4-bromo-1,2-phenylene)dimethanol(171011-37-3)
• EPA Substance Registry System: (4-bromo-1,2-phenylene)dimethanol(171011-37-3)

Safety Data

• Hazardous Substances Data: 171011-37-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(4-bromo-1,2-phenylene)dimethanol is used as a building block for the synthesis of various pharmaceuticals due to its unique structure and functional groups.
Used in Agrochemical Industry:
(4-bromo-1,2-phenylene)dimethanol is used as a building block for the synthesis of agrochemicals, contributing to the development of effective and targeted products for agricultural applications.
Used in Materials Science:
(4-bromo-1,2-phenylene)dimethanol is used as a building block in the synthesis of various materials, including polymers and resins, due to its ability to act as a crosslinking agent.
Used as a Crosslinking Agent in Polymer and Resin Production:
(4-bromo-1,2-phenylene)dimethanol is used as a crosslinking agent in the production of polymers and resins, enhancing their properties and performance.
Note: The handling of (4-bromo-1,2-phenylene)dimethanol should be done with caution, as brominated chemicals can pose hazards to human health and the environment if not properly managed.

Upstream product

• 583-71-1 4-bromo-o-xylene 
• 86-90-8 4-bromophthalic anhydride 
• 6968-28-1 4-bromophthalic acid 
• 87639-57-4 4-bromophthalic Acid Dimethyl Ester 
• 64169-34-2 5-bromophthalide 

Downstream Products

• 1609568-26-4 4-bromo-1,2-bis(1,3-dimethylimidazolin-2-ylideneaminomethyl)benzene 
• 1609573-80-9 4-bromo-1,2-bis(tert-butoxycarbonylaminoethyl)benzene 
• 1609574-30-2 (E)-methyl 3-[3,4-bis(tert-butoxycarbonylaminoethyl)phenyl]acrylate 
• 1609574-33-5 methyl 3-[3,4-bis(tert-butoxycarboinylaminoethyl)phenyl]propanoate 
• 1609574-36-8 3-[3,4-bis(tert-butoxycarboinylaminoethyl)phenyl]propan-1-ol 
• 660830-63-7 7-bromoisoquinoline-3-carboxylic acid 
• 660830-62-6 ethyl 7-bromoisoquinoline-3-carboxylate 
• 89424-83-9 1,3-dihydroisobenzofuran-5-carbaldehyde 

Relevant articles and documents

Live-Cell Localization Microscopy with a Fluorogenic and Self-Blinking Tetrazine Probe

Recent developments in fluorescence microscopy call for novel small-molecule-based labels with multiple functionalities to satisfy different experimental requirements. A current limitation in the advancement of live-cell single-molecule localization micro

Synthesis of 8-bromo-5,12-tetracenequinone and 2-bromotetracene derivatives

A series of bromotetracenequinones 1 and bromotetracenes 2 were prepared from 4-bromophthalic anhydride. The parent tetracenequinone 1a and tetracene 2a were sparingly soluble in organic solvents. In contrast, dipropyl-substituted tetracenequinone 1b and

CYCLIC PEPTIDE ANALOGS OF MELANOCORTIN AND AMANITIN AND METHODS OF MAKING SUCH

The invention described herein is based in part on the discovery of a protein/peptide crosslink, which introduces fluorescent properties, and which has been applied to synthesize analogues of melanocortin and amanitin as choice peptides to be explored in the context of isoindole peptides. Without limitation, it is expected that those trained in the art of peptide synthesis and stapling would appreciate the consequences of this invention such that other peptides of varied length can be similarly constrained by isoindole staples as featured herein.

Structure-Activity Studies with Bis-Amidines That Potentiate Gram-Positive Specific Antibiotics against Gram-Negative Pathogens

Pentamidine, an FDA-approved antiparasitic drug, was recently identified as an outer membrane disrupting synergist that potentiates erythromycin, rifampicin, and novobiocin against Gram-negative bacteria. The same study also described a preliminary structure-activity relationship using commercially available pentamidine analogues. We here report the design, synthesis, and evaluation of a broader panel of bis-amidines inspired by pentamidine. The present study both validates the previously observed synergistic activity reported for pentamidine, while further assessing the capacity for structurally similar bis-amidines to also potentiate Gram-positive specific antibiotics against Gram-negative pathogens. Among the bis-amidines prepared, a number of them were found to exhibit synergistic activity greater than pentamidine. These synergists were shown to effectively potentiate the activity of Gram-positive specific antibiotics against multiple Gram-negative pathogens such as Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli, including polymyxin- and carbapenem-resistant strains.

IDO/TDO Inhibitor

A compound of formula (I) given below or a pharmaceutically acceptable salt of the compound is useful as an IDO/TDO inhibitor. Thus, the compound of formula (I) or the pharmaceutically acceptable salt of the compound can be used as, for example, a therapeutic agent for a disease or a disorder selected from tumor, infectious disease, neurodegenerative disorder, cataract, organ transplant rejection, autoimmune disease, postoperative cognitive impairment, and disease related to women's reproductive health [in the following formula (I), ring A represents an aromatic ring, an aliphatic ring, a heterocyclic ring, or a condensed ring of two or more rings selected from an aromatic ring, an aliphatic ring and a heterocyclic ring; X, R1 and R2 represent a substituent on a ring atom constituting ring A; m represents an integer of 0 to 6; X represents, for example, a halogen atom; and R1 and R2 are the same or different and are selected from, for example, the group consisting of groups of formula (a) or formula (b); and in the following formula (a) and formula (b), Y is selected from the group consisting of O, S, and Se, Z is selected from the group consisting of O, S, and Se, n represents an integer of 1 to 8, r represents an integer of 1 to 8, s represents an integer of 1 to 8, R4 represents, for example, —C(═NH)—HN2, and R6 represents, for example, a substituted or unsubstituted aryl group].

Optimization of Orally Bioavailable PI3KδInhibitors and Identification of Vps34 as a Key Selectivity Target

Optimization of a lead series of PI3Kδinhibitors based on a dihydroisobenzofuran core led to the identification of potent, orally bioavailable compound 19. Selectivity profiling of compound 19 showed similar potency for class III PI3K, Vps34, and PI3Kδ, and compound 19 was not well-tolerated in a 7-day rat toxicity study. Structure-based design led to an improvement in selectivity for PI3Kδover Vps34 and, a focus on oral phramacokinetics properties resulted in the discovery of compound 41, which showed improved toxicological outcomes at similar exposure levels to compound 19.

FlICk (fluorescent isoindole crosslinking) for peptide stapling

The rigidification of peptide secondary structure via stapling is an important and enduring goal in the development of functional peptides for biochemical and pharmaceutical applications. In addition, the incorporation of fluorophores and chromophores has

Fluorescent Isoindole Crosslink (FlICk) Chemistry: A Rapid, User-friendly Stapling Reaction

The stabilization of peptide secondary structure via stapling is a ubiquitous goal for creating new probes, imaging agents, and drugs. Inspired by indole-derived crosslinks found in natural peptide toxins, we employed ortho-phthalaldehydes to create isoindole staples, thus transforming inactive linear and monocyclic precursors into bioactive monocyclic and bicyclic products. Mild, metal-free conditions give an array of macrocyclic α-melanocyte-stimulating hormone (α-MSH) derivatives, of which several isoindole-stapled α-MSH analogues (Ki≈1 nm) are found to be as potent as α-MSH. Analogously, late-stage intra-annular isoindole stapling furnished a bicyclic peptide mimic of α-amanitin that is cytotoxic to CHO cells (IC50=70 μm). Given its user-friendliness, we have termed this approach FlICk (fluorescent isoindole crosslink) chemistry.

Platinum-on-Carbon-Catalyzed Aqueous Oxidative Lactonization of Diols by Using Molecular Oxygen

A lactonization of various diols catalyzed by platinum on carbon (Pt/C) in water under an atmosphere of molecular oxygen was developed. Derivatives of 1,4- 1,5- and 1,6-diols were transformed into the corresponding five-, six-, and seven-membered lactones by the present oxidative lactonization method.

Site-Selective Functionalization of (sp3)C?H Bonds Catalyzed by Artificial Metalloenzymes Containing an Iridium-Porphyrin Cofactor

The selective functionalization of one C?H bond over others in nearly identical steric and electronic environments can facilitate the construction of complex molecules. We report site-selective functionalizations of C?H bonds, differentiated solely by rem