- Bicyclic fibrinogen antagonists
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PCT No. PCT/US95/00248 Sec. 371 Date Jul. 3, 1996 Sec. 102(e) Date Jul. 3, 1996 PCT Filed Jan. 9, 1995 PCT Pub. No. WO96/18619 PCT Pub. Date Jul. 13, 1995Certain compounds within formula (I) are inhibitors of platelet aggregation: wherein A1 is NH or CH2;
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- An Alternate Enantiospecific Synthesis of Methyl (S)-7-tert-Butoxycarbonyl-2,3,4,5-Tetrahydro-4-Methyl-3-Oxo-1H-1,4-Benzodiazepine-2-Acetate
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An alternate enantiospecific synthesis of methyl (S)-7-tert-butoxycarbonyl-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetate (5) is reported.The key step, which involves an intermolecular displacement of the activated aryl fluoride (9) by L-aspartic acid β-mehtyl ester, proceeds without racemization.
- Ku, Thomas W.,Ali, Fadia E.,Bondinell, William E.,Erhard, Karl F.,Huffmann, William F.,et al.
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p. 3131 - 3134
(2007/10/03)
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