171200-90-1Relevant articles and documents
A synthesis of (3R*,4R*)-Luffariolide E via 1,2-metallate rearrangement
Hareau-Vittini,Kocienski,Reid
, p. 1007 - 1013 (2007/10/02)
A key step in the synthesis of (3R*,4R*)-Luffariolide E is a 1,2-metallate rearrangement of a higher order cuprate to generate a trisubstituted double bond stereoselectively. The synthetic product is a diastereoisomer of the natural marine cytotoxic agent (3S,4R)-Luffariolide E.