171361-65-2

Basic information

• Product Name: Ethyl 1-oxaspiro[2.5]octane-6-carboxylate
• Synonyms: Ethyl 1-oxaspiro[2.5]octane-6-carboxylate;1-Oxaspiro[2.5]octane-6-carboxylic acid ethyl ester
• CAS NO: 171361-65-2
• Molecular Formula: C₁₀H₁₆O₃
• Molecular Weight: 184.23224
• Mol File: 171361-65-2.mol

Chemical Properties

• Boiling Point: 257℃
• Flash Point: 102℃
• Appearance: /
• Density: 1.10
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: Ethyl 1-oxaspiro[2.5]octane-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 1-oxaspiro[2.5]octane-6-carboxylate(171361-65-2)
• EPA Substance Registry System: Ethyl 1-oxaspiro[2.5]octane-6-carboxylate(171361-65-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 171361-65-2(Hazardous Substances Data)

Usage

Uses

Used in Perfumery Industry:
Ethyl 1-oxaspiro[2.5]octane-6-carboxylate is used as a fragrance ingredient in the perfumery industry for its pleasant scent, enhancing the aroma of various perfumes and other fragranced products.
Used in Pest Control Products:
In the pest control industry, Ethyl 1-oxaspiro[2.5]octane-6-carboxylate is used as an insecticide due to its potential insecticidal properties, helping to control and eliminate pests effectively.
Used in Sanitizers:
Ethyl 1-oxaspiro[2.5]octane-6-carboxylate is used as an antimicrobial agent in sanitizers, contributing to the prevention of the spread of bacteria and other microorganisms, thus promoting cleanliness and hygiene.
Used in Pharmaceutical Industry:
Ethyl 1-oxaspiro[2.5]octane-6-carboxylate is studied for its potential medicinal properties, such as anti-inflammatory and analgesic effects. It is used as a pharmaceutical compound for the development of drugs targeting inflammation and pain relief.

Upstream product

• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 
• 1774-47-6 trimethylsulfoxonium iodide 
• 2181-42-2 trimethylsulphonium iodide 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 186581-53-3 diazomethane 

Downstream Products

• 1044271-29-5 ethyl 4-hydroxy-4-[(phenylamino)methyl]cyclohexanecarboxylate 

Relevant articles and documents

I-OXA-3-AZASPIRO (4.5) DECAN-2-ONE AND 1-OXA-3, 8-DIAZASPIRO (4.5) DECAN-2-ONE DERIVATIVES FOR THE TREATMENT OF EATING DISORDERS

The present invention relates to novel compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, formula (I) wherein R is an aryl or heteroaryl; which may be substituted by one or more: halogen, C1 -C4 alkyl, C1-C4 alkoxy, C1 -C4 haloalkyl, C1 -C4 haloalkoxy, cyano; W is -CZ1 or nitrogen; Z1 is hydrogen, C1 -C4 alkyl; A is a 5 membered heteroaryl, pyrazine, pyrimidine, or quinoline or quinazoline which may be substituted by one or more: halogen, C1-C4 alkyl, C1-C4 alkoxy, C1 -C4 haloalkyl, C1 -C4 haloalkoxy, cyano; B is hydrogen or a 5-10 membered aryl or heteroaryl which may be substituted by one or more: halogen, C1-C4 alkyl, C1-C4 alkoxy, C1 -C4 haloalkyl, C1 -C4 haloalkoxy, cyano; being A and B linked via any atom; provided that when W is -CZ1, compounds of formula (I) have a trans stereochemistry; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as NPY Y5 receptor antagonists and as agents for the treatment and/or prophylaxis of eating disorders such as a binge eating disorder.

BENZIMIDAZOLES WITH A HETERO SPIRO-DECANE RESIDUE AS NPY-Y5 ANTAGONISTS

The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salts, solvates, stereoisomers thereof, formula (I), R1 may be C1-C4 alkyl, aryl or heteroaryl, which may be substituted by one or more: halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, cyano; R2 may be halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, cyano, nitro; or aryl, heteroaryl or heterocycle, which may be substituted by one or more: halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, cyano; or R2 may correspond to -0-R3; R3 is a 6-membered aromatic carbocyclic ring which may contain 1 or 2 nitrogen X is carbon or oxygen; Z is carbon or nitrogen; G is a fused 6-membered aromatic carbocyclic ring which may contain 1 or 2 nitrogen; m may be 0 or an integer ranging from 1 to 4; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as NPY- Y5 receptor antagonists.

Synthesis of 3- and 4-Substituted Cyclic α-Amino Acids Structurally Related to ACPD

The preparation of 3-substituted cyclopentanones 12-16, 4-substituted cyclohexanones 23-28 and cycloheptanones 38-41 is described.Substituents in the cycloalkanones are carboxylate, phosphonate or tetrazole groups, separated from the ring by a 0, 1, 2, or 3 carbon atoms chain.These cycloalkanones have been transformed into α-amino acids 9-11 by hydrolysis of the corresponding hydantoin derivatives 21, 37 and 62, obtained under Bucherer-Bergs reaction conditions.