17270-45-0

Basic information

• Product Name: methyl 4-(3-pyridyl)butyrate
• Synonyms: methyl 4-(3-pyridyl)butyrate
• CAS NO: 17270-45-0
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 0
• Mol File: 17270-45-0.mol

Chemical Properties

• Boiling Point: 283.7°Cat760mmHg
• Flash Point: 125.3°C
• Appearance: /
• Density: 1.063g/cm³
• Vapor Pressure: 0.00312mmHg at 25°C
• Refractive Index: 1.5
• CAS DataBase Reference: methyl 4-(3-pyridyl)butyrate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(3-pyridyl)butyrate(17270-45-0)
• EPA Substance Registry System: methyl 4-(3-pyridyl)butyrate(17270-45-0)

Safety Data

• Hazardous Substances Data: 17270-45-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 4405, 1991 DOI: 10.1016/S0040-4039(00)92182-8

InChI:InChI=1/C10H13NO2/c1-13-10(12)6-2-4-9-5-3-7-11-8-9/h3,5,7-8H,2,4,6H2,1H3

Upstream product

• 50-36-2 cocaine 
• 292638-85-8 acrylic acid methyl ester 
• 26364-02-3 hydrazone of pyridine-3-carboxaldehyde 
• 500-22-1 3-pyridinecarboxaldehyde 
• 1121-55-7 3-vinylpyridine 
• 2365-48-2 Methyl thioglycolate 

Relevant articles and documents

Copper-Catalyzed Conjugate Addition of Carbonyls as Carbanion Equivalent via Hydrazones

Copper-catalyzed conjugate addition is a classic method for forming new carbon-carbon bonds. However, copper has never showed catalytic activity for umpolung carbanions in hydrazone chemistry. Herein, we report a facile conjugate addition of hydrazone catalyzed by readily available copper complexes at room temperature. The employment of mesitylcopper(I) and electron-rich phosphine bidentate ligand is a key factor affecting reactivity. The reaction allows various aromatic hydrazones to react with diverse conjugated compounds to produce 1,4-adducts in yields of about 20 to 99%.

Reductive C-C Coupling by Desulfurizing Gold-Catalyzed Photoreactions

[Au2(μ-dppm)2]Cl2-mediated photocatalysis reactions are usually initiated by ultraviolet A (UVA) light; herein, an unreported system using blue light-emitting diodes (LEDs) as excitation light source was found. The red shift of the absorption wavelength originates from the combination of [Au2(μ-dppm)2]Cl2 and ligand (Ph3P or mercaptan). On the basis of this finding, a gold-catalyzed reductive desulfurizing C-C coupling of electrophilic radicals and styrenes mediated by blue LEDs is presented, a coupling which cannot be efficiently accessed by previously reported methods. This mild and highly efficient C-C bond formation strategy uses mercaptans both as electron-deficient alkyl radical precursor as well as the hydrogen source. Two examples of amino acids have also been modified by using this strategy. Moreover, this methodology could be applied in polymer synthesis. Gram-scale synthesis and mechanistic insights into this transformation are also presented.

Novel 1,8-naphthyridin-2(1h)-one derivatives

The purpose is to provide selective PDE IV inhibitors which have a potent anti-asthmatic profile with excellent safety. A compound of the formula (1): wherein: A is an unsubstituted or optionally substituted 5 or 6 membered heteroaryl group or a fused benzene ring in which any of the above-defined heteroaryl groups is fused to a benzene ring, B is carbon or nitrogen, R1 is hydrogen, lower alkyl, trifluoromethyl, hydroxyl, lower alkoxy, a residue derived from a carboxylic acid or a derivative thereof, amino, or an amino nitrogen-containing group, R2 is hydrogen, halogen, cyano, nitro, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, trifluoromethyl, hydroxyl, lower alkoxy, a residue derived from a carboxylic acid or a derivative thereof, amino, or an amino nitrogen-containing group, and m is an integer of from 1 to 8, both inclusive; or a pharmaceutically acceptable salt thereof possesses selective PDE IV inhibition and is useful as a pharmaceutical drug, preferably an anti-asthmatic, etc.