Conformationally constrained analogues of diacylglycerol. 12. Ultrapotent protein kinase C ligands based on a chiral 4,4-disubstituted heptono-1,4- lactone template
Conformationally constrained analogues of diacylglycerol (DAG) built on a 5-[(acyloxy)methyl [-5-(hydroxymethyl)tetrahydro-2-furanone template (1, Chart 1) were shown previously to bind tightly to protein kinase Cα (PK- Cα) in a stereospecific manner. The