An efficient chemoenzymatic approach to (S)-γ-fluoroleucine ethyl ester
(Chemical Equation Presented) An asymmetric synthesis of (S)-γ-fluoroleucine ethyl ester 1 is described. The key transformation involves a lipase-catalyzed dynamic ring-opening of 2-(3-butenyl)azlactone 7b with EtOH to give amide ester (S)-6b in 84% enant
Limanto, John,Shafiee, Ali,Devine, Paul N.,Upadhyay, Veena,Desmond, Richard A.,Foster, Bruce R.,Gauthier Jr., Donald R.,Reamer, Robert A.,Volante
p. 2372 - 2375
(2007/10/03)
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