A NEW SYNTHESIS OF 3-SUBSTITUTED INDOLINES AND INDOLES
3-Phenyl- and 3-alkyl-3-hydroxyindolines were synthesized by intramolecular Barbier reaction of phenyl and alkyl N-(2-iodophenyl)-N-methylaminomethyl ketones with n-BuLi, which were easily prepared from N-methyl-2-iodoaniline and bromomethyl ketones.The treatment of the indolines with acid gave the corresponding indoles in quantitative yields.
Kihara, Masaru,Iwai, Yasumasa,Nagao, Yoshimitsu
p. 2279 - 2288
(2007/10/03)
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