- DENDRIMER BASED COMPOSITIONS AND METHODS OF USING THE SAME
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The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer based compositions and systems for use in disease diagnosis and therapy (e.g., cancer diagnosis and therapy). The compositions and systems comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and monitoring the response to therapy of a cell or tissue (e.g., a tumor).
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- DENDRIMER BASED COMPOSITIONS AND METHODS OF USING THE SAME
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The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer based compositions and systems for use in disease diagnosis and therapy (e.g., cancer diagnosis and therapy). The c
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Page/Page column 103
(2008/06/13)
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- Naaladase inhibitors for treating retinal disorders and glaucoma
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The present invention relates to pharmaceutical compositions and methods for treating a retinal disorder or glaucoma using NAALADase inhibitors.
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- Synthesis and biological evaluation of (R)- and (S)-2-(phosphonomethyl)pentanedioic acids as inhibitors of glutamate carboxypeptidase II
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Both enantiomers of 2-(phosphonomethyl)pentanedioic acid (2-PMPA), a potent and selective inhibitor of glutamate carboxypeptidase II (GCP II), were successfully prepared through the resolution of racemic 2-(hydroxyphosphinoylmethyl)pentanedioic acid diben
- Vitharana, Dilrukshi,France, Jessica E.,Scarpetti, David,Bonneville, George W.,Majer, Pavel,Tsukamoto, Takashi
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p. 1609 - 1614
(2007/10/03)
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- NAALADase inhibitors useful as pharmaceutical compounds and compositions
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The present invention relates to N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) inhibitors enzyme activity, pharmaceutical compositions comprising such inhibitors, and methods of their use to inhibit NAALADase enzyme activity, thereby effecting neur
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- Naaladase inhibitors for treating amyotrophic lateral sclerosis
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The present invention relates to pharmaceutical compositions and methods for treating amyotrophic lateral sclerosis using NAALADase inhibitors.
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- Methods for treating certain diseases using naaladase inhibitors
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The present invention relates to methods of using NAALADase inhibitors to regulate TGF-β and to treat neurodegenerative disorders, extracellular matrix formation disorders, cell-growth related diseases, infectious diseases, immune related diseases, epithelial tissue scarring, collagen vascular diseases, fibroproliferative disorders, connective tissue disorders, inflammatory diseases, respiratory distress syndrome and infertility.
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- Prodrugs of NAALAdase inhibitors
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The present invention relates to prodrugs of NAALADase inhibitors, pharmaceutical compositions comprising the same, and methods of using the same to treat glutamate abnormalities and prostate diseases.
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- Methods for treating anxiety, anxiety disorders and memory impairment using naaladase inhibitors
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The present invention relates to methods of using NAALADase inhibitors for treating glutamate-mediated diseases, disorders and conditions selected from the group consisting of anxiety, anxiety disorders and memory impairment.
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- Methods of cancer treatment using naaladase inhibitors
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The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel methods of using phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives to inhibit N-Acetylated alpha -Linked Acidic Dipeptidase (NA
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- Certain dioic acid derivatives useful as NAALADase inhibitors
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The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated alpha -Linked Acidic Dipeptidase (NAALADase) enzyme
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- Asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives
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The present invention relates to asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives.
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- Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
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The present invention relates to a method of treating a glutamate abnormality and a method of effecting a neuronal activity in an animal using a NAALADase inhibitor, and a pharmaceutical composition comprising an effective amount of a NAALADase inhibitor
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- PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING COMPULSIVE DISORDERS USING NAALADASE INHIBITORS
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The present invention relates to a pharmaceutical composition and a method for treating a compulsive disorder using a NAALADase inhibitor.
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- CERTAIN PHOSPHONOMETHYL-PENTANEDIOIC ACID DERIVATIVES THEREOF
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The present disclosure relates to dipeptidase inhibitors, and more particularly, to N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) enzyme inhibitors which are proposed as novel agents for the treatment of prostate cancer. NAALADase is enzyme which i
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- Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase.
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A series of substituted phosphonate derivatives were designed and synthesized in order to study the ability of these compounds to inhibit the neuropeptidase N-acetylated alpha-linked acidic dipeptidase (NAALADase). The molecules were shown to act as inhib
- Jackson, Paul F.,Cole, Derek C.,Slusher, Barbara S.,Stetz, Susan L.,Ross, Laurie E.,et al.
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p. 619 - 622
(2007/10/03)
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