- CINNOLINE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASE TYPE IV (PDE4)
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There are provided according to the invention novel compounds of formula (I).
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Page/Page column 64-65
(2010/11/27)
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- 2-QUINOLONE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASES
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There is provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable solvates thereof.
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Page/Page column 18
(2008/06/13)
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- On the mechanism of deoxygenation of secondary alcohols by tin hydride reduction of methyl xanthates and other thiocarbonyl derivatives
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The room temperature deoxygenation of xanthates and thionocarbonates using (n - Bu) 3Sn-H - Et3B - air has been studied, especially with 119Sn N.M.R. spectroscopy. The orignal conception of tin radical attack on thiocarbonyl is confirmed.
- Barton,Jang,Jaszberenyi Cs.
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p. 3991 - 3994
(2007/10/02)
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- Organotin-Mediated Selective Desulfurization: Tri-n-butyltin Hydride Reduction of Unsymmetric Sulfides
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Tri-n-butyl hydride (TBTH) has been evaluated as a selective agent for the reductive cleavage of one C-S-bond in unsymmetric sulfides 1.Sulfides 1 (RR1) (where combinations of R and R1 included primary, secondary, tertiary, benzylic, phenyl, allylic, and α-(to carbonyl) carbon bound to sulfur> were each reacted with 1 equiv of TBTH in the presence of AIBN initiator.Reduction by TBTH occurs initially at the R1-S bond (where R1 can form the more stable carbon radical intermediate) in sulfide 1 selectively, if not specifically, to yield hydrocarbon 4 and tributylstannyl alkyl sulfide 3.However, this specifity can be negated by an enhanced reacitivity toward reduction by TBTH which the C-S bond in 3 exhibits, producing hydrocarbon 6 and bis(tributyltin) sulfide.The degree of selectivity in desulfurization is determined by the competition between unsymmetric sulfide 1 and alkyl organotin sulfide 3 for TBTH.The reduction of secondary and primary alkyl C-S bonds in 1 is so slow as to discount the synthetic utility of trialkyltin hydride reduction for such sulfides.
- Gutierrez, Carlos G.,Summerhays, Leo R.
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p. 5206 - 5213
(2007/10/02)
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- DIRECT SYNTHESIS OF PROTECTED THIOLS BY TRIBUTYLSTANNYL GROUP
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Organic thiocyanates react with tributyltin hydride under homolytic conditions to give thiostannanes (Bu3Sn-SR), which are air-stable and high boiling protected forms of the parent thiols.
- Ueno, Yoshio,Nozomi, Mamoru,Okawara, Makoto
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p. 1199 - 1202
(2007/10/02)
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