173156-91-7Relevant articles and documents
Assay for identification of compounds that promote melanin production and retinoid-like compounds identified by said assay
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, (2008/06/13)
An in vitro assay for selecting compounds that alter pigmentation of skin is provided. Also, a novel class of pro-pigmentatory compounds is provided which comprise substituted aromatic or heterocyclic carboxylic acids, or derivatives thereof, or pharmaceutically acceptable salts, which do not contain a pheno, naphthol, thiophenol, or a thionaphthol function in free or protected form. In a preferred embodiment, thess compounds will display activity for RXRs. These compounds may be used for altering pigmentation of human skin and/or hair in cosmetic or dermatological compositions, and for the treatment of disorders and disease conditions that affect skin or hair pigmentation.
Composition containing at least one bicyclic aromatic compound and at least one lipophilic sunscreen, and uses thereof
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, (2008/06/13)
A composition containing at least one lipophilic sunscreen and at least one bicyclic aromatic compound represented by formula (I): or a salt or chiral analogue of such a compound, where the structural variables R1, Ar, X, R2 Y and X are defined herein, and at least one lipophilic sunscreen.
RXR-agonist polycyclic aromatic compounds, pharmaceutical/cosmetic compositions comprising said compound and uses thereof
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, (2008/06/13)
Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds having the structural formula (I): wherein Ar is a radical having one of the formulae (a)-(e): which are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders are provided. In particular, based on their RXR-agonist activity, these compounds may be used to treat noninsulin-dependent diabetes mellitus (NIDDM) and obesity.
Retinoid inhibition of expression of VEGF
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, (2008/06/13)
The retinoids, in particular the anti-AP-1 retinoids, effectively inhibit the expression of VEGF, and thus are useful for the therapeutic treatment of disease states manifesting an overexpression of VEGF.
Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid
Beard, Richard L.,Colon, Diana F.,Song, Tae K.,Davies, Peter J. A.,Kochhar, Devendra M.,Chandraratna, Roshantha A. S.
, p. 3556 - 3563 (2007/10/03)
Retinoids exert their biological effects by binding to and activating nuclear receptors that interact with responsive elements on DNA to promote gene transcription. There are two families of retinoid receptors, the retinoic acid receptor (RAR) family and