- Microwave-assisted regioselective synthesis of acyclic nucleosides through an alkylating reaction with 2-oxa-1,4-butanediol diacetate
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An efficient and green procedure for the synthesis of purine acyclic nucleosides through microwave-assisted, alkylation of various purine nucleobases with 2-oxa-1,4-butanediol diacetate in the absence of solvent and catalyst is described. The advantages of using this method include its environmental friendliness, simple manipulation, short reaction time, high regioselectivity, and good yields.
- Qu, Guirong,Han, Suhui,Zhang, Zhiguang,Geng, Mingwei,Xue, Feng
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- REGIOSELECTIVE SYNTHESIS OF 9--6-BENZYLAMINOPURINE ANALOGUE OF ACYCLOVIR
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The 6-benzylaminopurine 1 has been alkylated with (2-acetoxyethoxy)methylbromide 3, using trimethylsilylation and phase transfer catalysis procedures.The influence of the base, the solvent and the catalyst were studied.When the solid-liquid phase transfer
- Taha, Mohamed L.,Lazrek, Hassan B.
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p. 591 - 594
(2007/10/02)
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