Generation of functionalized azomethine ylides and their application to stereoselective heterocycle synthesis: an equivalent process of C-unsubstituted nitrile ylide cycloaddition reaction
The synthetic process equivalent to C-unsubstituted (CH) nitrile ylides cycloaddition reaction is achieved via cycloaddition of NH-azomethine ylide and the following fission reaction of the cycloadducts under acidic conditions. Cycloaddition of NH-azometh
RICERCHE SU DERIVATI PIRIDOPIRIMIDINICI. Nota I - Sintesi di 4-(dialchilammino)-2H-piridopirimidin-2-oni.
Reaction of the N,N-dialkylethoxycarbonylacetamide-POCl3 reactant with 2-aminopyridine in refluxing dichloroethane yielded 4-(dialkylamino)-2H-pyridopyrimidine-2-ones (IV) together with generally lower quantities of isomeric 2-(dialkylamino)-4H-pyridopyrimidin-4-ones (V).Some compounds (V) were obtained also by reaction of 2-chloro-4H-pyridopyrimidin-4-one (VI) with the suitable amine in confirmation of their structure.In addition, the differences in the properties and in the spectroscopic characteristics of the two classes of isomers are reported.
Roma, G.,Ermili, A.,Braccio, M. Di,Mazzei, M.
p. 747 - 758
(2007/10/02)
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