- PCSK9 ANTAGONIST COMPOUNDS
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Disclosed are compounds of Formula (A), or a pharmaceutically acceptable salt thereof: where A, X, R1, and R2 are as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula (I) or their salts, and methods of treating cardiovascular disease and conditions related to PCSK9 activity, e.g. atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions.
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Page/Page column 159; 161
(2021/03/05)
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- Syntheses of Polypeptides by Hidrogenolysis of N-Benzyloxycarbonyl-Amino Acid Anhydrides
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When anhydrides of N-benzyloxycarbonyl-DL-aspartic acid (Z-DL-Asp), Z-L-Asp, N-Z-DL-glutamic acid (Z-DL-Glu), Z-L-Glu and N-Z-3-aminoglutaric acid (Z-β-Agl) were hydrogenolyzed in N,N-dimethylformamide (DMF), polypeptides were obtained in high yields.Hydrogenolyses of Z-DL-Glu and Z-L-Glu in dioxane gave pyroglutamic acid.
- Munegumi, Toratane,Meng, Yan-Quing,Harada, Kaoru
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p. 2748 - 2750
(2007/10/02)
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- Potential antitumor agents. 45. Synthesis, DNA-binding interaction, and biological activity of triacridine derivatives
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A series of amide-linked triacridines of varying interchromophore separation were synthesized as potential DNA trisintercalating agents. The correseponding diamide diacridines (lacking the central chromophore) were also prepared, and the DNA-binding and b
- Atwell,Baguley,Wilmanska,Denny
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