cas 17343-07-6, H-GLY-GLY-TYR-OH | Articles data

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The Use of Crown Ethers in Peptide Chemistry IV. Solid Phase Synthesis of Peptides Using Peptide Fragments Nα Protected With 18-Crown-6
The conditions under which peptide synthesis by the fragment condensation approach in the solid phase can be carried out using crown ethers as non-covalent protecting groups for the Nα amino group of peptides were determined.The dipeptide Gly-Gly was complexed with 18-crown-6 to establish the feasibility of this new protection scheme and to optimise the reaction conditions.Nearly quantitative incorporation of the complex onto resin-bound amino acids possessing either proline or an Nα-alkylated amino acids was achieved using DCM as the activation and coupling reactions solvent.The use of DMF as the solvent and resin-bound primary amino acids were found detrimental to the reaction yields due to the removal of the crown ether protection.Extending the length of the peptide fragment to model pentapeptide complexes bearing no reactive functionalities on the side-chain gave essentially quantitative incorporation yields in the coupling reactions to both resin-bound amino acids and short peptides.The non-covalent nature of the protection afforded by the crown molecule allowed its mild removal from resin-bound complexes by rapid treatments with 1percent DIEA solutions.Thus the continuation of chain assembly was possible.The results obtained served as the basis for extending the concept of non-covalent protection to the side chains of Lys and Arg containing peptides.
Botti, Paolo,Ball, Haydn L.,Rizzi, Emanuele,Lucietto, Pierluigi,Pinori, Massimo,Mascagni, Paolo
p. 5447 - 5458
(2007/10/02)

High-performance liquid chromatographic analysis of pulmonary metabolites of Leu- and Met-enkephalins in isolated perfused rat lung
A high-performance liquid radiochromatographic analytical system has been developed which allows the determination of [3H]Leu-enkephalin, [3H]Met-enkephalin and their potential metabolites [3H]TyrGlyGlyPhe, [3H]TyrGlyGly, [3H]TyrGly and [3H]tyrosine. Using this procedure, the biotransformation of each of the above enkephalins after 20 min of recirculating transit through isolated perfused rat lungs resulted in the formation of two major metabolites: tyrosine and TyrGlyGly in each case. The results indicate that significant metabolism of enkephalins may occur in the pulmonary circulation.
Crooks,Krechniak,Olson,Gillespie
p. 1010 - 1012
(2007/10/02)

Chemical Properties

Appearance/Colour :White to off white powder
Boiling Point: 720.2 °C at 760 mmHg
Flash Point:389.4 °C
Density: 1.381 g/cm³
Solubility:DMSO (Slightly, Heated), Water (Slightly, Heated)
Storage Temp.:-15°C
Vapor Pressure: 9.02E-22mmHg at 25°C
Refractive Index: 1.6
PSA: 141.75000
LogP: 0.06110

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Chemical Properties

Appearance/Colour :White to off white powder

Boiling Point: 720.2 °C at 760 mmHg

Flash Point:389.4 °C

Density: 1.381 g/cm³

Solubility:DMSO (Slightly, Heated), Water (Slightly, Heated)

Storage Temp.:-15°C

Vapor Pressure: 9.02E-22mmHg at 25°C

Refractive Index: 1.6

PSA: 141.75000

LogP: 0.06110

Global suppliers and manufacturers of 17343-07-6total 19 suppliers on LookChem

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17343-07-6

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Chemical Properties

Appearance/Colour :White to off white powder

Boiling Point: 720.2 °C at 760 mmHg

Flash Point:389.4 °C

Density: 1.381 g/cm3

Solubility:DMSO (Slightly, Heated), Water (Slightly, Heated)

Storage Temp.:-15°C

Vapor Pressure: 9.02E-22mmHg at 25°C

Refractive Index: 1.6

PSA: 141.75000

LogP: 0.06110

Global suppliers and manufacturers of 17343-07-6total 19 suppliers on LookChem

Density: 1.381 g/cm³