- Total synthesis of padanamides A and B
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The first total syntheses of padanamides A and B have been achieved, unambiguously confirming their structures. The Royal Society of Chemistry.
- Long, Bohua,Tang, Shoubin,Chen, Ligong,Qu, Shiwei,Chen, Bo,Liu, Junyang,Maguire, Anita R.,Wang, Zhuo,Liu, Yuqing,Zhang, Hui,Xu, Zhengshuang,Ye, Tao
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supporting information
p. 2977 - 2979
(2013/05/22)
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- Hexahydropyridazine-3-carboxylic acid hydrazide and hydrazone derivatives, combinatorial libraries containing same, pharmaceutical compositions containing same and methods of preparation
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The present invention discloses and claims hexahydropyridazine-3-carboxylic acid hydrazides and hydrazones of formula (I) as inhibitors of proteases and kinases, and methods of using said compounds of formula (I) for the prevention or treatment of certain
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Page/Page column 7-8
(2008/06/13)
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- Hexahydropyridazine-3-carboxylic acid derivatives, pharmaceutical compositions containing same and methods of preparation
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The present invention discloses and claims compounds of formula (I) as inhibitors of proteases and kinases, method using said compounds of formula (I) for the prevention or treatment of certain cardiovascular, central nervous system, inflammatory, and bon
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Page/Page column 9
(2010/02/13)
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- Lipase TL-mediated kinetic resolution of 5-benzyloxy-1-tert-butyldimethylsilyloxy-2-pentanol at low temperature: Concise asymmetric synthesis of both enantiomers of a piperazic acid derivative
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Lipase TL-mediated kinetic resolution of (± )-5-benzyloxy-1-tert-butyldimethylsilyloxy-2-pentanol (5) at low temperature proceeded to give the corresponding (S)-alcohol 5 and (R)-acetate 6 in quantitative yields with high enantiomeric purity. The addition of bases such as pyridine, DMAP, 2,4- and 2,6-lutidines, or triethylamine considerably enhanced the rate of kinetic resolution. The alcohol (S)-5 and the acetate (R) -6 were converted to piperazic acid derivatives (R)- and (S)-3, respectively, via the intramolecular Mitsunobu reaction as a key step.
- Aoyagi, Yutaka,Saitoh, Yoshihiro,Ueno, Tasuku,Horiguchi, Mai,Takeya, Koichi,Williams, Robert M.
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p. 6899 - 6904
(2007/10/03)
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- Enantioselective syntheses of (R)- and (S)-hexahydropyridazine-3-carboxylic acid derivatives
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Appropriately protected optically active tetrahydropyridazine-3-carboxylic acid and hexahydropyridazine-3-carboxylic acid were prepared via ring closure of α-hydrazino- and δ-hydrazinopentanoates. Either optically active glutamic acid or an enantioselective catalytic hydrogenation was used to generate the chiral center. The numerous optically active intermediates are valuable starting materials for the synthesis of other unusual amino acids.
- Schmidt, Ulrich,Braun, Christine,Sutoris, Heinz
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p. 223 - 229
(2007/10/03)
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- SYNTHESIS OF A NOVEL 6,5-BICYCLIC HEXAHYDROPYRIDAZINE DERIVATIVE
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A covergent synthesis of the 6,5-bicyclic hexahydropyridazine derivative (3) is described in which (3S)-N1-Cbz-piperazic acid methyl ester (4) is coupled with the functionalized carboxylic acid fragment (9).The Sharpless asymmetric dihydroxylat
- Dragovich, Peter S.,Tada, Hiroki,Zhou, Ru
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p. 2487 - 2498
(2007/10/03)
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