An efficient construction of 4-oxo-1,3-diazabicyclo[3.3.0]octanes via thiohydantoins
New stereoisomeric N-bridged heterocycles, 4-oxo-1,3-diazabicyclo-[3.3.0]octanes (4) were synthesized from trans-4-hydroxy-L-proline (1). Thiohydantoins 3 as the key intermediates were prepared by nucleophilic addition of 1 to isothiocyanates, and subsequent cyclization. These thiohydantoins 3 were readily desulfurized to provide 4.
Kim,Yoo,Shin,Kim,Park
p. 4001 - 4010
(2007/10/03)
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