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4-Hydroxyphenformin is a primary metabolite of the anti-diabetic drug phenformin, belonging to the class of organic compounds known as phenol ethers. It is one of the most potent biguanides in terms of its ability to inhibit mitochondrial complex I, which has the potential to induce antitumor effects. As an organic compound, it contains the elements of carbon, hydrogen, and oxygen, characterized by a 4-hydroxyphenyl group attached to phenformin. Although phenformin was withdrawn from various markets due to the risk of lactic acidosis, 4-hydroxyphenformin maintains considerable interest in diabetes and cancer research due to its systemic activities and pharmacological effects. 4-hydroxyphenformin has been predominantly identified in human urine samples.

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  • 17426-94-7 Structure
  • Basic information

    1. Product Name: 4-hydroxyphenformin
    2. Synonyms: 4-hydroxyphenformin
    3. CAS NO:17426-94-7
    4. Molecular Formula: C10H15N5O
    5. Molecular Weight: 221.259
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 17426-94-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 414.7°Cat760mmHg
    3. Flash Point: 204.6°C
    4. Appearance: /
    5. Density: 1.38g/cm3
    6. Vapor Pressure: 1.81E-07mmHg at 25°C
    7. Refractive Index: 1.651
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 4-hydroxyphenformin(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-hydroxyphenformin(17426-94-7)
    12. EPA Substance Registry System: 4-hydroxyphenformin(17426-94-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 17426-94-7(Hazardous Substances Data)

17426-94-7 Usage

Uses

Used in Pharmaceutical Industry:
4-Hydroxyphenformin is used as a research compound for its potential antitumor effects, as it is a potent inhibitor of mitochondrial complex I. This property makes it a valuable candidate for studying the mechanisms of cancer cell metabolism and the development of new cancer therapies.
Used in Diabetes Research:
4-Hydroxyphenformin is used as a research tool in diabetes research, given its origin as a metabolite of the anti-diabetic drug phenformin. Its study can provide insights into the metabolic pathways affected by biguanide drugs and contribute to the development of safer and more effective treatments for diabetes.
Used in Cancer Research:
4-Hydroxyphenformin is used as a potential antitumor agent in cancer research, due to its ability to inhibit mitochondrial complex I. This inhibition can lead to the disruption of cancer cell metabolism, making it a promising candidate for the development of new cancer treatments.
Used in Drug Metabolism Studies:
4-Hydroxyphenformin is used as a marker in drug metabolism studies, as it is a primary metabolite of phenformin. Its presence in human urine samples can help researchers understand the metabolic pathways and potential side effects associated with the use of phenformin and related drugs.

Check Digit Verification of cas no

The CAS Registry Mumber 17426-94-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,4,2 and 6 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 17426-94:
(7*1)+(6*7)+(5*4)+(4*2)+(3*6)+(2*9)+(1*4)=117
117 % 10 = 7
So 17426-94-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H15N5O/c11-9(12)15(10(13)14)6-5-7-1-3-8(16)4-2-7/h1-4,16H,5-6H2,(H3,11,12)(H3,13,14)

17426-94-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-hydroxyphenformin

1.2 Other means of identification

Product number -
Other names N1-<2-(p-Hydroxyphenyl)aethyl>biguanid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:17426-94-7 SDS

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