Synthesis and properties of N(α)-(tert-butyloxycarbonyl)peptide p- guanidinophenyl esters as trypsin substrates
N(α)-(tert-Butyloxycarbonyl)peptide p-guanidinophenyl esters were synthesized by amidination of N(α)-(tert-butyloxycarbonyl)peptide p- aminophenyl esters with 1-[N,N'-bis(benzyloxycarbonyl)amidino]pyrazole, followed by deprotection by catalytic hydrogenation, in good total yields. These synthetic esters were characterized as specific substrates for trypsin, and kinetic parameters for the trypsin-catalyzed hydrolysis are presented.
Itoh,Sekizaki,Toyota,Tanizawa
p. 2082 - 2087
(2007/10/03)
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