17437-19-3

Basic information

• Product Name: 13-Aminotridecanoic acid
• Synonyms: 13-Aminotridecanoic acid
• CAS NO: 17437-19-3
• Molecular Formula: C₁₃H₂₇NO₂
• Molecular Weight: 229.36
• Mol File: 17437-19-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 13-Aminotridecanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 13-Aminotridecanoic acid(17437-19-3)
• EPA Substance Registry System: 13-Aminotridecanoic acid(17437-19-3)

Safety Data

• Hazardous Substances Data: 17437-19-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
13-Aminotridecanoic acid is used as a precursor for the preparation of betulinic acid derivatives, which exhibit HIV-1 inhibitory activity. These derivatives have the potential to be developed into effective antiretroviral agents, contributing to the fight against HIV-1 and its associated complications.

Upstream product

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Relevant articles and documents

Process for producing long chain amino acids and dibasic acids

There is disclosed a process for the production of long chain amino acid and long chain dibasic acid, comprising: (1) reacting long chain keto fatty acid with hydroxylamine or subjecting keto fatty acid to an ammoximation reaction to yield an oxime fatty acid; (2) subjecting the oxime fatty acid to the Beckmann rearrangement to yield a mixture of two amide fatty acids; (3) hydrolyzing the mixed amide fatty acids to produce long chain amino acid, long chain dibasic acid, short chain alkylamine, and alkanoic acid.

Microbial synthesis of medium-chain α,ω-dicarboxylic acids and ω-aminocarboxylic acids from renewable long-chain fatty acids

Biotransformation of long-chain fatty acids into medium-chain α,ω-dicarboxylic acids or ω-aminocarboxylic acids could be achieved with biocatalysts. This study presents the production of α,ω-dicarboxylic acids (e.g., C9, C11, C 12, C13) and ω-aminocarboxylic acids (e.g., C 11, C12, C13) directly from fatty acids (e.g., oleic acid, ricinoleic acid, lesquerolic acid) using recombinant Escherichia coli-based biocatalysts. ω-Hydroxycarboxylic acids, which were produced from oxidative cleavage of fatty acids via enzymatic reactions involving a fatty acid double bond hydratase, an alcohol dehydrogenase, a Baeyer-Villiger monooxygenase and an esterase, were then oxidized to α,ω- dicarboxylic acids by alcohol dehydrogenase (ADH, AlkJ) from Pseudomonas putida GPo1 or converted into ω-aminocarboxylic acids by a serial combination of ADH from P. putida GPo1 and an ω-transaminase of Silicibacter pomeroyi. The double bonds present in the fatty acids such as ricinoleic acid and lesquerolic acid were reduced by E. coli-native enzymes during the biotransformations. This study demonstrates that the industrially relevant building blocks (C9 to C13 saturated α,ω- dicarboxylic acids and ω-aminocarboxylic acids) can be produced from renewable fatty acids using biocatalysis.