174466-48-9

Basic information

• Product Name: methyl -glycinate
• Synonyms: methyl -glycinate
• CAS NO: 174466-48-9
• Molecular Weight: 268.291
• Mol File: 174466-48-9.mol

Chemical Properties

• CAS DataBase Reference: methyl -glycinate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl -glycinate(174466-48-9)
• EPA Substance Registry System: methyl -glycinate(174466-48-9)

Safety Data

• Hazardous Substances Data: 174466-48-9(Hazardous Substances Data)

Upstream product

• 1189-71-5 isocyanate de chlorosulfonyle 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 75-65-0 tert-butyl alcohol 
• 147000-89-3 N-tert-butyloxycarbonylsulfamoyl chloride 
• 616-34-2 methoxycarbonylmethylamine 

Downstream Products

• 174466-50-3 methyl -glycinate 
• 1370228-82-2 2-((N-(tert-butoxycarbonyl)-N-(3-phenoxybenzyl)sulfamoyl)amino)acetic acid 
• 1370228-97-9 methyl 2-((N-(tert-butoxycarbonyl)-N-(3-phenoxybenzyl)sulfamoyl)(methyl)amino)acetate 
• 1370228-99-1 2-((N-(tert-butoxycarbonyl)-N-(3-phenoxybenzyl)sulfamoyl)(methyl)amino)acetic acid 
• 263719-76-2 tert-butyl 1,2,5-thiadiazolidine-2-carboxylate1,1-dioxide 
• 332367-41-6 C₁₄H₂₁ClN₂O₄S 

Relevant articles and documents

Inhibition pattern of sulfamide-related compounds in binding to carbonic anhydrase isoforms I, II, VII, XII and XIV

A set of sulfamides and sulfamates were synthesized and tested against several isoforms of carbonic anhydrase: CA I, CA II, CA VII, CA XII and CA XIV. The biological assays showed a broad range of inhibitory activity, and interesting results were found for several compounds in terms of activity (Ki 1 μm) and selectivity: some aromatic sulfamides are active against CA I, CA II and/or CA VII; while they are less active in CA XII and CA XIV. On the other hand, bulky sulfamides are selective to CA VII. To understand the origin of the different inhibitory activity against each isozyme we used molecular modeling techniques such as docking and molecular dynamic simulations.

Potent norovirus inhibitors based on the acyclic sulfamide scaffold

The development of small molecule therapeutics to combat norovirus infection is of considerable interest from a public health perspective because of the highly contagious nature of noroviruses. A series of amino acid-derived acyclic sulfamide-based norovirus inhibitors has been synthesized and evaluated using a cell-based replicon system. Several compounds were found to display potent anti-norovirus activity, low toxicity, and good aqueous solubility. These compounds are suitable for further optimization of pharmacological and ADMET properties.

Synthesis and anticonvulsant activity of amino acid-derived sulfamides

Sulfamides are promising functions for the design of new antiepileptic drugs (Bioorg. Med. Chem. 2007, 15, 1556-1567; 5604-5614). Following previous research in this line, a set of amino acid-derived sulfamides has been designed, synthesized, and tested a

Synthesis of 1,2,5-thiadiazolidines 1,1-dioxides (Cyclosulfamides) starting from amino acids and chlorosulfonyl isocyanate

We report here a practical access to a series of five-membered cyclosulfamides (1,2,5-thiadiazolidines 1,1-dioxides) N2 substituted by the BOC group. These compounds are synthesized starting from chlorosulfonyl isocyanate and nitrogen mustards or amino acids. The derivatization of amino acids can lead to an alkyl group on C-4 with a well-defined configuration; in this case the N5 position was protected by a benzyl group. These compounds are valuable tools for asymmetric synthesis. (C) 2000 Elsevier Science Ltd.

Synthesis of pseudonucleosides containing chiral sulfahydantoins as aglycone (II)

A series of chiral sulfahydantoins have been synthesized by alkaline cyclization starting from N-sulfamylaminoacid methyl esters. Regioselective glycosylation of these pseudopyrimidic heterocycles was carried out with a benzyl protecting group on the N-su