- Preparation method of N-alkoxy oxalyl alanine ester
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The invention discloses a preparation method of N-alkoxy oxalyl alanine ester, which comprises the following steps: (1) under the action of triphosgene and an organic alkali, carrying out an esterification reaction on alanine and an alcohol to obtain alanine ester hydrochloride; and (2) under the action of the organic alkali, carrying out an amidation reaction on the alanine ester hydrochloride obtained in the step (1) and oxalic ester, and after the reaction is finished, carrying out post-treatment to obtain the N-alkoxy oxalyl alanine ester. According to the preparation method, the triphosgene and the organic alkali are used as reaction additives, so that the use of toxic solvent benzene is avoided, the reaction time is shortened, the product purity and the reaction yield are high, and the preparation method is suitable for industrial production.
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Paragraph 0040-0041
(2019/12/02)
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