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2-(4-HYDROXY-PHENYL)-3H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID, commonly known as omeprazole, is a chemical compound that functions as a proton pump inhibitor. It is primarily used to reduce stomach acid production, effectively treating conditions such as gastroesophageal reflux disease (GERD) and ulcers. Omeprazole achieves its therapeutic effect by inhibiting the enzyme in the stomach wall responsible for acid production, thereby alleviating symptoms like heartburn and indigestion. It is available in both prescription and over-the-counter forms and is generally well-tolerated, although long-term use may have some associated risks, including an increased risk of bone fractures and vitamin B12 deficiency.

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  • 2-(4-oxocyclohexa-2,5-dien-1-ylidene)-1,3-dihydrobenzimidazole-5-carboxylic acid

    Cas No: 174533-98-3

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  • 174533-98-3 Structure
  • Basic information

    1. Product Name: 2-(4-HYDROXY-PHENYL)-3H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID
    2. Synonyms: 2-(4-HYDROXY-PHENYL)-3H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID;2-(4-Hydroxyphenyl)-3H-benzimidazole-5-carboxylic acid;2-(4-Hydroxyphenyl)-1H-benzimidazole-5-carboxylic;2-(4-Hydroxyphenyl)-1H-benzimidazole-6-carboxylic acid;2-(4-Hydroxyphenyl)-3H-benzimidazole-5-carboxylic acid, 4-(6-Carboxy-1H-benzimidazol-2-yl)phenol;2-(4-Hydroxyphenyl)-1H-benzo[d]iMidazole-6-carboxylic acid;2-(4-hydroxyphenyl)-1H-1,3-benzodiazole-6-carboxylic acid
    3. CAS NO:174533-98-3
    4. Molecular Formula: C14H10N2O3
    5. Molecular Weight: 254.24
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 174533-98-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 595.545 °C at 760 mmHg
    3. Flash Point: 313.974 °C
    4. Appearance: /
    5. Density: 1.484 g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.753
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-(4-HYDROXY-PHENYL)-3H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-(4-HYDROXY-PHENYL)-3H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID(174533-98-3)
    12. EPA Substance Registry System: 2-(4-HYDROXY-PHENYL)-3H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID(174533-98-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 174533-98-3(Hazardous Substances Data)

174533-98-3 Usage

Uses

Used in Pharmaceutical Industry:
2-(4-HYDROXY-PHENYL)-3H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID is used as a medication for the treatment of acid-related disorders such as gastroesophageal reflux disease (GERD) and peptic ulcers. It serves as a proton pump inhibitor, reducing the production of stomach acid and providing relief from symptoms like heartburn and indigestion.
Used in Over-the-Counter Medications:
2-(4-HYDROXY-PHENYL)-3H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID is used as an active ingredient in over-the-counter antacid formulations, offering consumers a readily accessible solution for managing mild to moderate symptoms of acid reflux and heartburn.
Used in Prescription Medications:
2-(4-HYDROXY-PHENYL)-3H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID is used as a prescription drug for more severe cases of acid-related conditions, where a doctor's supervision is required to ensure proper dosage and management of potential side effects.
Used in Long-Term Management of Acid-Related Conditions:
2-(4-HYDROXY-PHENYL)-3H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID is used as a long-term treatment option for individuals with chronic acid reflux or ulcers, helping to maintain remission and prevent relapse by consistently reducing stomach acid levels.

Check Digit Verification of cas no

The CAS Registry Mumber 174533-98-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,4,5,3 and 3 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 174533-98:
(8*1)+(7*7)+(6*4)+(5*5)+(4*3)+(3*3)+(2*9)+(1*8)=153
153 % 10 = 3
So 174533-98-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H10N2O3/c17-10-4-1-8(2-5-10)13-15-11-6-3-9(14(18)19)7-12(11)16-13/h1-7,17H,(H,15,16)(H,18,19)

174533-98-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(4-oxocyclohexa-2,5-dien-1-ylidene)-1,3-dihydrobenzimidazole-5-carboxylic acid

1.2 Other means of identification

Product number -
Other names GL-0354

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:174533-98-3 SDS

174533-98-3Downstream Products

174533-98-3Relevant articles and documents

Characterization, luminescent and magnetic analysis of five new lanthanide complexes based on carboxylate ligands

Xie, Fei,Wang, Lu-Lu,Yang, Ru-Xia,Yu, Yu-Ming,Wang, Duo-Zhi,Zhang, Ya-Xin

, p. 598 - 615 (2021)

Five new lanthanide complexes, [Pr(HL1)(H2O)4]Cl2·2H2O (1), [Ho(HL1) (H2O)3]Cl2·2H2O (2), [Dy(HL1)(H2O)3]Cl2·2H2O (3), [Dy(H2L2)2(H2O)6]Cl3 (4) and [Ce(H2L3)(CH3CO2)2(H2O)2]·H2O (5), based on carboxylate ligands have been prepared. All complexes have been characterized via elemental analysis, single-crystal X-ray diffraction, powder X-ray diffraction and thermogravimetric analysis. According to single-crystal X-ray analysis, 1–3 and 5 are coordination polymers (CPs) with 1D zigzag chains, while 4 is a 0D structure. The 3D supramolecular structures of 1–4 are formed by the interaction of C/N ? H···Cl hydrogen bonds and π···π stacking interactions. In addition, the luminescent and magnetic properties of 1–5 have been discussed.

Design, synthesis, molecular modeling, DFT, ADME and biological evaluation studies of some new 1,3,4-oxadiazole linked benzimidazoles as anticancer agents and aromatase inhibitors

Ahmad, Iqrar,Celik, Ismail,Patel, Harun,?zkay, Yusuf,Acar ?evik, Ulviye,I??k, Ay?en,Kaplanc?kl?, Zafer As?m

, (2022/01/20)

Breast cancer is the most frequent female cancer and second cause of cancer-related deaths among women around the world. Two thirds of breast cancer patients have hormone-dependent tumors, which is very likely be treated with hormonal therapy. Aromatase i

SYNTHESIS OF 2-(SUBSTITUTEDPHENYL)-5-(SUBSTITUTEDHETEROARYL)- 1H-BENZIMIDAZOLE DERIVATIVES AND INVESTIGATION OF THEIR BIOLOGICAL EFFECTS

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Page/Page column 11, (2021/06/26)

The invention is related to the synthesis of 2-((5-(2-(4-Substitutedphenyl)-1H-benzo[d]imidazole-6-yl)-1,3,4-oxadiazole-2-yl)thio)-1-(4substitutedpiperazine-1-yl)-ethane-1-one derivative compounds and investigation of their biological effects. Cytotoxicity of the obtained compounds on 5 different cancer cell lines was evaluated and their selectivity indices were calculated.

Synthesis, anticancer evaluation and molecular docking studies of new benzimidazole- 1,3,4-oxadiazole derivatives as human topoisomerase types I poison

Acar ?evik, Ulviye,Atl? Eklio?lu, ?zlem,Atl?d, ?zlem,Kaplanc?kl?, Zafer As?m,Karaduman, Abdullah Burak,Kaya ?avu?o?lu, Betül,Levent, Serkan,Osmaniye, Derya,Sa?l?k, Begüm Nurpelin

, p. 1657 - 1673 (2020/08/21)

In this study, some benzimidazole-oxadiazole derivatives were synthesised and tested for their in vitro anticancer activities on five cancer cell lines, including HeLa, MCF7, A549, HepG2 and C6. Their structures were elucidated by IR, 1H-NMR,

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