174566-19-9

Basic information

• Product Name: 2,4-Dichloro-8-nitroquinazoline
• Synonyms: 2,4-Dichloro-8-nitroquinazoline
• CAS NO: 174566-19-9
• Molecular Formula: C8H3Cl2N3O2
• Molecular Weight: 244.03432
• Mol File: 174566-19-9.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,4-Dichloro-8-nitroquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichloro-8-nitroquinazoline(174566-19-9)
• EPA Substance Registry System: 2,4-Dichloro-8-nitroquinazoline(174566-19-9)

Safety Data

• Hazardous Substances Data: 174566-19-9(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2,4-Dichloro-8-nitroquinazoline is used as a precursor in organic synthesis for the development of new chemical compounds. Its structure allows for further chemical reactions and modifications, making it a valuable building block in the creation of complex organic molecules.
Used in Pharmaceutical Research:
In pharmaceutical research, 2,4-Dichloro-8-nitroquinazoline is utilized as a starting material for the synthesis of potential drug candidates. Its unique chemical properties and reactivity make it suitable for the development of various drugs and agrochemicals, contributing to the advancement of medical and agricultural solutions.
Used in Agrochemical Development:
2,4-Dichloro-8-nitroquinazoline is also employed in the development of agrochemicals, such as pesticides and herbicides. Its chemical structure and properties can be harnessed to create effective compounds that protect crops and enhance agricultural productivity.
It is crucial to handle 2,4-Dichloro-8-nitroquinazoline with care and adhere to safety guidelines to minimize potential hazards and risks associated with its use.

Upstream product

• 174565-61-8 8-nitro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline 
• 606-18-8 3-nitroanthranilic acid 

Relevant articles and documents

Discovery of 2-(2-aminopyrimidin-5-yl)-4-morpholino-N-(pyridin-3-yl)quinazolin-7-amines as novel PI3K/mTOR inhibitors and anticancer agents

In this study, a series of novel 7 or 8-substituted 4-morpholine-quinazoline derivatives was designed and synthesized. Their PI3Kα inhibitory activities, antiproliferative activities against seven cancer cell lines, namely, PC-3, DU145, MCF-7, BT474, SK-BR-3, U937 and A431, were evaluated in vitro. Compound 17f proved to be a potential drug candidate with high PI3Kα inhibition activity (IC50 = 4.2 nM) and good antiproliferative activity. Compound 17f was also tested for its inhibitory activities against other kinases, such as PI3Kβ, PI3Kγ, PI3Kδ and mTOR, its effects on p-Akt (S473) and cell cycle. These results suggested that compound 17f could significantly inhibit the PI3K/Akt/mTOR pathway as a potent PI3K inhibitor and anticancer agent.

Tricyclic dicarbonyl derivatives

Compounds of general formula (Ia), (Ib) and (II), wherein R1 and R2 each independently signify hydrogen, lower alkyl, lower alkoxy, nitro, trifluoromethyl, amino, halogen, cyano or R3 R4 NS(O)2 -- and R3 and R4 signify lower alkyl, and R2 can additionally signify morpholino or thiomorpholino, a 5- or 6-membered heterocycle with 1-3N atoms optionally substituted by lower alkyl, hydroxy, amino or the group --CH2 NHCH3, a bicyclic heterocycle with 1-3N atoms or a group --NR5 R6 or --OR5 in which R5 and R6 can be the same or different and signify hydrogen, lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, amino-lower alkyl or lower alkylamino-lower alkyl, and X in formula (II) signifies --CH=CH--, --CH=N--, --NH--, --CO-- or --O--, as well as pharmaceutically usable salts of compounds of general formula (Ia), (Ib) and (II). They can be used for the treatment or prevention of illnesses, especially for the treatment or prevention of ischemia, hypoglycaemia, hypoxia, cerebral vascular spasms, spasticity, trauma, hemorrhagia, infection (viral, bacterial, amoebic, prional), epileptic seizures, autoimmune diseases, withdrawal symptoms, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, intoxications, olivoponto-cerebellar atrophy, spinal cord injuries, schizophrenia, depressions, anxiety states, dependence, pains,autism and mental retardation.