174636-76-1

Basic information

• Product Name: 2-methoxy-1-phenylethanamine
• Synonyms: 2-methoxy-1-phenylethanamine;(R,S)-2-Methoxy-1-phenylethylamine;2-METHOXY-1-PHENYLETHAN-1-AMINE
• CAS NO: 174636-76-1
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.21
• Mol File: 174636-76-1.mol

Chemical Properties

• Boiling Point: 230.2±20.0 °C(Predicted)
• Appearance: /
• Density: 1.011±0.06 g/cm3(Predicted)
• PKA: 8.90±0.10(Predicted)
• CAS DataBase Reference: 2-methoxy-1-phenylethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxy-1-phenylethanamine(174636-76-1)
• EPA Substance Registry System: 2-methoxy-1-phenylethanamine(174636-76-1)

Safety Data

• Hazardous Substances Data: 174636-76-1(Hazardous Substances Data)

Upstream product

• 74-88-4 methyl iodide 
• 20989-17-7 Phenylglycinol 
• 4079-52-1 methoxymethyl phenyl ketone 

Downstream Products

• 127104-22-7 N-hydroxy-2-methoxy-1-phenylethanamine 
• 127104-33-0 N-ethylidene-2-methoxy-1-phenylethanamine N-oxide 
• 127104-34-1 N-propylidene-2-methoxy-1-phenylethanamine N-oxide 
• 127104-32-9 N-benzylidene-2-methoxy-1-phenylethanamine N-oxide 
• 127104-46-5 (1R*,1'R*)-N-hydroxy-N-(2'-methoxy-1-phenylethyl)-2-butanamine 
• 127104-46-5 (1R*,1'S*)-N-hydroxy-N-(2'-methoxy-1-phenylethyl)-2-butanamine 
• 127104-44-3 (1R*,1'R*)-N-hydroxy-N-(2'-methoxy-1'-phenylethyl)-1-phenylethanamine 
• 127104-44-3 (1R*,1'S*)-N-hydroxy-N-(2'-methoxy-1'-phenylethyl)-1-phenylethanamine 
• 1066676-24-1 C₂₆H₂₈N₄O₂ 
• 1395342-20-7 2-(2-methoxy-1-phenylethylamino)-1,1,2-triphenylethanol 
• 690629-64-2 N-benzylidene-2-methoxy-1-phenylethanamine 
• 127104-18-1 N-(benzoyloxy)-2-methoxy-1-phenylethanamine 

Relevant articles and documents

SIGMA-1 RECEPTOR LIGANDS AND THERAPEUTIC USES THEREOF

The present invention relates to the field of medicine. More specifically, the present invention relates to compounds that are sigma-1 receptor agonists and their use for the treatment of central nervous system disorders, including cognitive or neurodegen

Method for preparing primary amine by catalyzing reductive amination of aldehyde ketone compounds

The invention discloses a method for preparing primary amine by catalyzing reductive amination of aldehyde ketone compounds. The method comprises the following steps: 1) mixing nickel nitrate hexahydrate, citric acid and an organic solvent, carrying out heating and stirring until a colloidal material is obtained, drying the colloidal material, roasting the colloidal material in a protective atmosphere, pickling, washing and drying a roasted product, and performing a partial oxidation reaction on a dried product in an oxygen-nitrogen mixed atmosphere to obtain a catalyst for a reductive amination reaction; and 2) mixing aldehyde or ketone compounds, a methanol solution of ammonia and the reductive amination reaction catalyst, introducing hydrogen, and carrying out a reductive amination reaction. The method has the advantages of high primary amine yield, high selectivity, wide aldehyde ketone substrate range, short reaction time, mild reaction conditions, low cost, greenness, economicalperformance and the like; the used reductive amination reaction catalyst can be recycled more than 10 times, and the catalytic activity of the catalyst is not obviously changed in gram-level reactions; and the method is suitable for large-scale application.

Titanium-mediated cross-coupling reactions of imines with ketones or aldehydes: An efficient route for the synthesis of 1,2-amino alcohols

The cross-coupling reactions of imines with ketones using Ti(O iPr)4/c-C5H9MgCl reagent lead to 1,2-amino alcohols after hydrolysis. The coupling reactions with aldehydes could also afford 1,2-amino alcohols, however, in some cases, aziridines were obtained as major products in a stereoselective manner.