174671-50-2

Basic information

• Product Name: 5-(TRIFLUOROMETHYL)BENZO[C][1,2]OXABOROL-1(3H)-OL
• Synonyms: 5-(TRIFLUOROMETHYL)BENZO[C][1,2]OXABOROL-1(3H)-OL;2-Hydroxymethyl-5-(trifluoromethyl)phenylboronic acid
• CAS NO: 174671-50-2
• Molecular Formula: C8H6BF3O2
• Molecular Weight: 201.94
• Mol File: 174671-50-2.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 5-(TRIFLUOROMETHYL)BENZO[C][1,2]OXABOROL-1(3H)-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(TRIFLUOROMETHYL)BENZO[C][1,2]OXABOROL-1(3H)-OL(174671-50-2)
• EPA Substance Registry System: 5-(TRIFLUOROMETHYL)BENZO[C][1,2]OXABOROL-1(3H)-OL(174671-50-2)

Safety Data

• Hazardous Substances Data: 174671-50-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
5-(TRIFLUOROMETHYL)BENZO[C][1,2]OXABOROL-1(3H)-OL is used as a reagent for forming carbon-carbon and carbon-heteroatom bonds in organic synthesis. Its unique structure allows it to participate in various reactions, such as Suzuki-Miyaura cross-coupling and Sonogashira coupling, to create a wide range of biologically active molecules and functional materials. This makes it a versatile component in the development of pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 959687-85-5 1-bromo-2-(dimethoxymethyl)-4-(trifluoromethyl)benzene 
• 102684-91-3 2-bromo-5-(trifluoromethyl)benzaldehyde 
• 905710-73-8 2-bromo-5-trifluoromethyl-1-(methoxymethoxymethyl)benzene 
• 869725-53-1 (2-bromo-5-(trifluoromethyl)phenyl)methanol 

Relevant articles and documents

Synthesis, structure, properties and antimicrobial activity of para trifluoromethyl phenylboronic derivatives

The [2-formyl-4-(trifluoromethyl)phenyl]boronic acid as well as its benzoxaborole and bis(benzoxaborole) derivatives were obtained and their properties studied. The 2-formyl compound displays an unusual structure in the crystalline state, with a significa

BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS

Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.

Compounds for the Treatment of Periodontal Disease

Compounds, compositions and methods are provided which are useful in the treatment of periodontal disease.

Boron-containing small molecules

This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro- 1-hydroxy-2,1-benzoxaborole (AN2690), for the potential treatment of onychomycosis

A structure-activity relationship investigation for a more efficacious therapy to treat onychomycosis, a fungal infection of the toe and fingernails, led to the discovery of a boron-containing small molecule, 5-fluoro-1,3-dihydro- 1-hydroxy-2,1-benzoxaborole (AN2690), which is currently in clinical trials for onychomycosis topical treatment.