- Chiral β - substituted - α, β - unsaturated amino alcohol compound preparation method
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The invention discloses a preparation method of a chiral beta-substituted-alpha, beta-unsaturated amino alcohol compound. In the presence of a solvent and a chiral catalyst of palladium, beta-substituted alpha, beta-unsaturated carbonic ester compound (I) performs asymmetric allylic substituted reaction in nitrogen atmosphere to generate chiral beta-substituted-alpha, beta-unsaturated amino alcohol (II). The preparation method of the invention has the advantages mild conditions and simple operation, and can realize good reaction yield and enantioselectivity; therefore, the invention has good application prospect.
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Paragraph 0122; 0123
(2017/08/31)
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