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2-(2,4-Difluorophenoxy)-3-nitropyridine is a chemical compound characterized by the molecular formula C10H6F2N2O3. It is a pyridine derivative featuring a nitro group at the 3rd position and a difluorophenoxy group at the 2nd position on the pyridine ring. 2-(2,4-DIFLUOROPHENOXY)-3-NITROPYRIDINE is recognized for its versatile reactivity and notable biological activity, which makes it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals. Furthermore, it exhibits intriguing properties that contribute to its utility in the development of new materials and functional molecules, with potential applications extending to the realms of organic electronics and materials science.

175135-62-3

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175135-62-3 Usage

Uses

Used in Pharmaceutical Synthesis:
2-(2,4-Difluorophenoxy)-3-nitropyridine is utilized as a key intermediate in the development of pharmaceuticals, leveraging its unique structural features to enhance the properties of resulting drug molecules. Its incorporation can lead to improved pharmacokinetics, potency, and selectivity of the final drug products.
Used in Agrochemical Development:
In the agrochemical industry, 2-(2,4-Difluorophenoxy)-3-nitropyridine serves as a crucial component in the synthesis of novel pesticides and herbicides. Its chemical properties allow for the creation of compounds with enhanced efficacy and selectivity against target pests and weeds, while minimizing environmental impact.
Used in Fine Chemicals Production:
2-(2,4-DIFLUOROPHENOXY)-3-NITROPYRIDINE is employed as a building block in the production of fine chemicals, which are high-purity chemicals used in various applications such as fragrances, flavors, and specialty chemicals. Its unique structure contributes to the creation of fine chemicals with specific properties tailored to their intended uses.
Used in Organic Electronics:
2-(2,4-Difluorophenoxy)-3-nitropyridine is used as a component in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and organic photovoltaics (OPVs). Its electronic properties and chemical stability make it a promising candidate for improving the performance and durability of these devices.
Used in Materials Science:
In the field of materials science, 2-(2,4-Difluorophenoxy)-3-nitropyridine is applied in the research and development of new materials with unique properties. Its incorporation can lead to the creation of materials with enhanced mechanical, thermal, or electrical characteristics, depending on the specific application.

Check Digit Verification of cas no

The CAS Registry Mumber 175135-62-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,5,1,3 and 5 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 175135-62:
(8*1)+(7*7)+(6*5)+(5*1)+(4*3)+(3*5)+(2*6)+(1*2)=133
133 % 10 = 3
So 175135-62-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H8F2N2O/c12-7-3-4-10(8(13)6-7)16-11-9(14)2-1-5-15-11/h1-6H,14H2

175135-62-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(2,4-DIFLUOROPHENOXY)-3-NITROPYRIDINE

1.2 Other means of identification

Product number -
Other names 2,6-DIMETHOXY-3,7-BIS(METHYLSELENO)-NAPHTHALENE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:175135-62-3 SDS

175135-62-3Relevant articles and documents

Chemical validation of a druggable site on Hsp27/HSPB1 using in silico solvent mapping and biophysical methods

Makley, Leah N.,Johnson, Oleta T.,Ghanakota, Phani,Rauch, Jennifer N.,Osborn, Delaney,Wu, Taia S.,Cierpicki, Tomasz,Carlson, Heather A.,Gestwicki, Jason E.

, (2021/02/09)

Destabilizing mutations in small heat shock proteins (sHsps) are linked to multiple diseases; however, sHsps are conformationally dynamic, lack enzymatic function and have no endogenous chemical ligands. These factors render sHsps as classically “undruggable” targets and make it particularly challenging to identify molecules that might bind and stabilize them. To explore potential solutions, we designed a multi-pronged screening workflow involving a combination of computational and biophysical ligand-discovery platforms. Using the core domain of the sHsp family member Hsp27/HSPB1 (Hsp27c) as a target, we applied mixed solvent molecular dynamics (MixMD) to predict three possible binding sites, which we confirmed using NMR-based solvent mapping. Using this knowledge, we then used NMR spectroscopy to carry out a fragment-based drug discovery (FBDD) screen, ultimately identifying two fragments that bind to one of these sites. A medicinal chemistry effort improved the affinity of one fragment by ~50-fold (16 μM), while maintaining good ligand efficiency (~0.32 kcal/mol/non-hydrogen atom). Finally, we found that binding to this site partially restored the stability of disease-associated Hsp27 variants, in a redox-dependent manner. Together, these experiments suggest a new and unexpected binding site on Hsp27, which might be exploited to build chemical probes.

Synthesis of N-[2-(2,4-difluorophenoxy)trifluoromethyl-3-pyridyl]- sulfonamides and their inhibitory activities against secretory phospholipase A2

Nakayama, Hitoshi,Ishihara, Keiichi,Akiba, Satoshi,Uenishi, Jun'ichi

experimental part, p. 1069 - 1072 (2011/10/02)

N-[2-(2,4-Difluorophenoxy)trifluoromethyl-3-pyridyl]sulfonamide derivatives 3-6 were prepared by the reaction of 3-pyridylamines and sulfonyl chlorides. Inhibitory activities of these compounds toward secretory phospholipase A 2 (sPLA2/su

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