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2-Ethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine-3,5-dione, commonly known as etazene, is a benzoxazepine derivative that is a white solid with a molecular formula of C11H11NO3 and a molar mass of 209.21 g/mol. It is recognized for its potent opioid effects and has been used as a narcotic analgesic drug in some countries. However, due to its high risk of addiction, abuse, and overdose, it has been classified as a controlled substance in many jurisdictions and is not approved for medical use in the United States and several other countries.

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  • 175136-47-7 Structure
  • Basic information

    1. Product Name: 2-ETHYL-2,3,4,5-TETRAHYDRO-1,4-BENZOXAZEPINE-3,5-DIONE
    2. Synonyms: 2-ETHYL-2,3,4,5-TETRAHYDRO-1,4-BENZOXAZEPINE-3,5-DIONE;2-ETHYLOXAZEPINE-3,5-DIONE;2-ethyl-1,4-benzoxazepine-3,5-dione
    3. CAS NO:175136-47-7
    4. Molecular Formula: C11H11NO3
    5. Molecular Weight: 205.21
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 175136-47-7.mol
  • Chemical Properties

    1. Melting Point: 162 °C
    2. Boiling Point: 392.2°C at 760 mmHg
    3. Flash Point: 191°C
    4. Appearance: /
    5. Density: 1.195g/cm3
    6. Vapor Pressure: 2.33E-06mmHg at 25°C
    7. Refractive Index: 1.529
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-ETHYL-2,3,4,5-TETRAHYDRO-1,4-BENZOXAZEPINE-3,5-DIONE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-ETHYL-2,3,4,5-TETRAHYDRO-1,4-BENZOXAZEPINE-3,5-DIONE(175136-47-7)
    12. EPA Substance Registry System: 2-ETHYL-2,3,4,5-TETRAHYDRO-1,4-BENZOXAZEPINE-3,5-DIONE(175136-47-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 175136-47-7(Hazardous Substances Data)

175136-47-7 Usage

Uses

Used in Pharmaceutical Industry:
Etazene is used as a narcotic analgesic for its potent opioid effects, providing pain relief. However, its use is limited due to the high risk of addiction, abuse, and overdose, which has led to its classification as a controlled substance in many jurisdictions.
Used in Regulatory and Legal Contexts:
Etazene is used as a reference in regulatory and legal frameworks to define and control substances with high potential for abuse. Its classification as a controlled substance helps in monitoring and restricting its distribution and use to prevent misuse and associated health risks.

Check Digit Verification of cas no

The CAS Registry Mumber 175136-47-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,5,1,3 and 6 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 175136-47:
(8*1)+(7*7)+(6*5)+(5*1)+(4*3)+(3*6)+(2*4)+(1*7)=137
137 % 10 = 7
So 175136-47-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H11NO3/c1-2-8-11(14)12-10(13)7-5-3-4-6-9(7)15-8/h3-6,8H,2H2,1H3,(H,12,13,14)

175136-47-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-ethyl-1,4-benzoxazepine-3,5-dione

1.2 Other means of identification

Product number -
Other names HMS547N20

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:175136-47-7 SDS

175136-47-7Downstream Products

175136-47-7Relevant articles and documents

Synthesis and properties of new 2-alkyl-1,4-benzoxazepine derivatives. Part I. Synthesis and cyclization of 2-phenoxyalkanoic acid derivatives

Kwiecien

, p. 733 - 741 (2007/10/03)

2-Alkyl-1,4-benzoxazepin-3,5-diones (8) were readily prepared by cyclodehydration of 2-(o-carbamoilphenoxy)alkanoic acids (7) in acetic anhydride, and with low yields by the same reaction of 2-(o-carboxyphenoxy)alkanoic acid amides (4). The novel acid amides 4 were synthesized from salicylaldehyde and 2-bromo esters 1, via formyl amides 3. The acid amides 7 were formed directly by condensation of salicylamides with 2-bromo esters 1 in dimethyl formamide or by hydrolysis of esters 6 obtained by the same reaction in methyl-ethyl ketone solution.

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