Synthesis of thiophene carboxamide derivatives as serotonin 5-HT4 receptor agonists
New thiophene carboxamide derivatives 3 (a-j) were synthesized as serotonin 5-HT4 receptor agonists. Preliminary results showed that the compounds 3a, 3d, 3e and 3f caused concentration dependent relaxation of carbachol-induced contraction in tunica muscularis mucosae in rat oesophagus.
Monge,Palop,Perez,Oset,Lasheras
p. 89 - 92
(2007/10/03)
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