A convergent strategy towards febrifugine and related compounds
We report a modular five step synthetic route to the febrifugines that employs 2-(chloromethyl)allyl-trimethylsilane as a conjunctive reagent for the coupling of the piperidine and quinazolinone groups. We also demonstrate the application of a recent Rh-catalyzed quinazolinone synthesis for the facile generation of febrifugine analogs.
Maiden,Mbelesi,Procopiou,Swanson,Harrity
p. 4159 - 4169
(2018/06/12)
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