175203-54-0

Basic information

• Product Name: 1-[5-(2-PHENYLETH-1-YNYL)-2-THIENYL]ETHAN-1-ONE
• Synonyms: 1-[5-(2-PHENYLETH-1-YNYL)-2-THIENYL]ETHAN-1-ONE;2-ACETYL-5-(PHENYLETHYNYL)THIOPHENE;1-[5-(2-phenylethynyl)thiophen-2-yl]ethan-1-one
• CAS NO: 175203-54-0
• Molecular Formula: C14H10OS
• Molecular Weight: 226.29
• Mol File: 175203-54-0.mol

Chemical Properties

• Boiling Point: 403.2°Cat760mmHg
• Flash Point: 197.6°C
• Appearance: /
• Density: 1.21g/cm³
• Vapor Pressure: 1.04E-06mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: 1-[5-(2-PHENYLETH-1-YNYL)-2-THIENYL]ETHAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[5-(2-PHENYLETH-1-YNYL)-2-THIENYL]ETHAN-1-ONE(175203-54-0)
• EPA Substance Registry System: 1-[5-(2-PHENYLETH-1-YNYL)-2-THIENYL]ETHAN-1-ONE(175203-54-0)

Safety Data

• Hazardous Substances Data: 175203-54-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry Research:
1-[5-(2-PHENYLETH-1-YNYL)-2-THIENYL]ETHAN-1-ONE is used as a research compound for exploring its chemical properties and potential reactivity in organic chemistry. Its unique structure allows scientists to investigate its behavior in various chemical reactions and interactions.
Used in Drug Development:
In the pharmaceutical and medicinal chemistry industries, 1-[5-(2-PHENYLETH-1-YNYL)-2-THIENYL]ETHAN-1-ONE is used as a potential candidate for drug development. Its distinctive molecular structure may offer new avenues for the creation of novel therapeutic agents, although further research is required to fully understand its potential applications and optimize its use in this field.
Additional research is necessary to delve deeper into the properties and potential applications of 1-[5-(2-PHENYLETH-1-YNYL)-2-THIENYL]ETHAN-1-ONE, ensuring that its full potential can be harnessed across various scientific and industrial domains.

InChI:InChI=1/C14H10OS/c1-11(15)14-10-9-13(16-14)8-7-12-5-3-2-4-6-12/h2-6,9-10H,1H3

Upstream product

• 536-74-3 phenylacetylene 
• 5370-25-2 2-Acetyl-5-bromothiophene 
• 88-15-3 2-Acetylthiophene 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 637-44-5 phenylpropyolic acid 
• 206551-43-1 (5-acetylthiophen-2-yl)boronic acid 

Downstream Products

• 317335-10-7 3-hydroxy-1-(5-phenethylthiophen-2-yl)-3-(1-trityl-1H-imidazol-2-yl)propan-1-one 
• 317335-11-8 3-hydroxy-3-(1H-imidazol-2-yl)-1-(5-phenethylthiophen-2-yl)propan-1-one 
• 317334-25-1 1-(1H-Imidazol-2-yl)-3-(5-phenethyl-thiophen-2-yl)propane-1,3-dione trifluoroacetate 

Relevant articles and documents

Alkynylboranes: A practical approach by zinc-catalyzed dehydrogenative coupling of terminal alkynes with 1,8-naphthalenediaminatoborane

Under zinc Lewis acid catalysis, terminal alkynes coupled dehydrogenatively with 1,8-naphthalenediaminatoborane [HB(dan)]. It is important to note that the resulting alkynylboranes with an C(sp) - B(dan) bond are isolable by column chromatography on silica gel (SiO2) and are usable as coupling partners for palladium- and copper-catalyzed cross-coupling reactions with (hetero)aryl halides.

Palladium-catalyzed oxidative cross-coupling between heterocycles and terminal alkynes with low catalyst loading

Direct: With [Pd2(dba)3] as a catalyst, the direct alkynylation of thiophenes bearing a variety of substituents has been accomplished by using terminal alkynes as alkynylating reagents. This protocol is also applicable to other electron-rich aromatic heterocycles. dba=dibenzylidenacetone. Copyright

Mild Pd/Cu-catalyzed sila-sonogashira coupling of (hetero)aryl bromides with (hetero)arylethynylsilanes under PTC conditions

The palladium/copper cocatalyzed sila-Sonogashira reaction of (hetero)arylethynysilanes with (hetero)aryl bromides in toluene and water at 40 C under PTC conditions gave the required di(hetero)arylethynes in moderate to high yields. Activated, deactivated and ortho-substituted (hetero)aryl bromides are well tolerated. This protocol also allowed the preparation of symmetrical diarylethynes by double arylation of 1,2-bis(trimethylsilyl)ethyne. Georg Thieme Verlag Stuttgart · New York.

Palladium-catalyzed decarboxylative cross-coupling of alkynyl carboxylic acids with arylboronic acids

A highly efficient and mild palladium-catalyzed decarboxylative cross-coupling of aryl boronic acids and alkynyl carboxylic acids for the synthesis of unsymmetrical substituted alkynes is described for the first time.

Palladhim-catalyzed decarboxylative sp-sp2 cross-coupling reactions of aryl and vinyl halides and triflates with α,β-ynoic acids using silver oxide

Palladium-catalyzed decarboxylative sp-sp2 cross-coupling reactions of aryl and vinyl halides and triflates with α,β-ynoic acids using silver oxide have been developed. A variety of α,β-ynoic acids were readily decarboxylated in the presence of