A new route to γ-arylidenebutyrolactones via a tandem carbopalladation-heterocyclisation sequence: A formal synthesis of U-68,215
Benzo-annulated enol lactones are obtained in good yields from pentynoic acids 3- or 5-substituted with an iodo-aryl moiety by palladium-catalyzed cyclization of their potassium carboxylates. Using this approach, an efficient new route to U-68,215 is described.
Palladium-mediated intramolecular cyclization of substituted pentynoic acids. A new route to γ-arylidenebutyrolactones
Benzo-annulated enol lactones are obtained in good yields from pentynoic acids 3- or 5- substituted with an iodo-aryl moiety by palladium-catalyzed cyclization of their potassium carboxylates.
Cavicchioli,Bouyssi,Gore,Balme
p. 1429 - 1432
(2007/10/03)
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